Chemoresistance is an obstacle of improving pancreatic cancer (PC) prognosis. However,
the biological function of ISG15 in PC and whether it correlates with the resistance to …

Tumor cells frequently evolved resistance to cisplatin that greatly compromises the efficacy
of chemotherapy. Identification of the mechanisms underlying drug resistance is important …

ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (Ubl), playing roles not only as an unconjugated form but also as a covalently …

Background Colon cancer is one of the most common cancers worldwide. IFN-stimulated
gene 15 (ISG15), a ubiquitin-like molecule, is strongly up-regulated by type I interferon as a …

Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide. Interferon‐α
(IFN‐α) has been widely used in the treatment of HCC, but patients eventually develop …

Background Studies have indicated that ATG3 could mediate the effects of other tumor-
related regulators in carcinogenesis. However, the expression, role, and mechanism of …

OBJECTIVE: ATG14, as an autophagy-related protein, has been shown to be implicated in
the progression of tumors by modulating cell autophagy. We aimed at exploring ATG14 level …

Kim MS, Song SY, Lee JY, Yoo NJ, Lee SH. Expressional and mutational analyses of ATG5
gene in prostate cancers. APMIS 2011; 119: 802–7. Autophagy is an evolutionarily …

Autophagy is reported to suppress tumor proliferation, whereas deficiency of autophagy is
associated with tumorigenesis. ATG4B is a deubiquitin-like protease that plays dual roles in …

Objectives: Gemcitabine is the standard chemotherapeutic agent for pancreatic cancer.
Nevertheless, the prognosis of pancreatic cancer patients is still poor. Evaluating the …