Understanding the inflammatory response to myocardial ischemia is an important part of
achieving the elusive clinical goal of perfect myocardial protection. While it is established …

Aims Myocardial infarction followed by adverse left ventricular (LV) remodeling is the most
frequent proximate cause of heart failure. Hydrogen sulfide (H 2 S) is an important …

The mammary gland of mammals possesses the specific function of synthesizing, secreting,
and delivering milk. Notably, mammary epithelial cells are considered to be central to control …

Activation of GPER exerts a protective effect in hypertension and ischemia-reperfusion
models and relaxes arteries in vitro. However, our understanding of the mechanisms of …

Females have a lower incidence of heart failure and improved survival after myocardial
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …

Estrogen exerts protective effects against cardiovascular diseases in premenopausal
women, but is associated with an increased risk of both coronary heart disease and stroke in …

The role of the newly discovered estrogen receptor GPR30 in islet physiology and
pathophysiology is unclear. We examined GPR30 expression in relation to hormone …

The sex hormone 17β-estradiol (E2) is the most abundant and active estrogen in
premenopausal women. Studies have shown that high circulating levels of E2 are …

Aims G protein-coupled receptor 35 (GPR35) has been characterized to be one of the genes
that are up-regulated in human heart failure. Since mechanisms controlling GPR35 …

Heart failure (HF) is a complex clinical syndrome with poor clinical outcomes despite the
growing number of therapeutic approaches. It is characterized by interstitial fibrosis …