Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …

Inflammation is a major driver of cardiac remodeling. Cardiac fibroblasts play an integral role
in cardiac inflammation, fibrosis and remodeling. The orphan G-protein-coupled-receptor 5B …

We found that the selective stimulation of the intracellular, transmembrane G protein–
coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure …

The G protein-coupled estrogen receptor 1 (GPER) produces cardioprotective effects.
However, the underlying mechanisms are not well understood. We aimed to investigate the …

Background—Epidemiological studies have shown gender differences in the incidence of
congestive heart failure (CHF); however, the role of estrogen in CHF is not known. We …

Earlier studies have shown that estrogen possess protective function against the
development of pathological cardiac hypertrophy. However, the molecular mechanisms of …

Background/Aims: Ischemia-reperfusion (I/R) injury is believed to be the major cause for
detriments in coronary heart diseases, but few effective therapies for prevention or treatment …

This review examines the mechanism of estrogen signaling in cardiomyocytes, with an
emphasis on mechanisms that might be important in cardioprotection. It investigates …

Estrogen receptors mediate numerous favorable effects on cells and molecules implicated in
vascular inflammation and atherogenic process. However, harmful effects have also been …

Objective Effect of estrogenic compounds and 17β-estradiol (E2), which induces endothelial
cell motility, was investigated on ROCK-2 expression in rat coronary vascular endothelial …