Fine particle matters induce DNA damage and G2/M cell cycle arrest in human bronchial epithelial BEAS-2B cells

J Wu, Y Shi, CO Asweto, L Feng, X Yang… - … Science and Pollution …, 2017 - Springer
There is compelling evidence that exposure to particulate matter (PM) is linked to lung
tumorigenesis. However, there is not enough experimental evidence to support the specific …

Repeated inhalations of diesel exhaust particles and oxidatively damaged DNA in young oxoguanine DNA glycosylase (OGG1) deficient mice

L Risom, M Dybdahl, P MØller, H Wallin… - Free radical …, 2007 - Taylor & Francis
DNA repair may prevent increased levels of oxidatively damaged DNA from prolonged
oxidative stress induced by, eg exposure to diesel exhaust particles (DEP). We studied …

Functional characterization of global genomic DNA repair and its implications for cancer

PC Hanawalt, JM Ford, DR Lloyd - Mutation Research/Reviews in Mutation …, 2003 - Elsevier
The most versatile cellular pathway for dealing with a large variety of structurally-unrelated
DNA alterations is nucleotide excision repair (NER). Most genomic damage, if not repaired …

Organic extracts of urban air pollution particulate matter (PM2. 5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells)

SM Oh, HR Kim, YJ Park, SY Lee, KH Chung - Mutation Research/Genetic …, 2011 - Elsevier
Traffic is a major source of particulate matter (PM), and ultrafine particulates and traffic
intensity probably contribute significantly to PM-related health effects. As a strong …

Effects of short‐term exposure to inhalable particulate matter on DNA methylation of tandem repeats

L Guo, HM Byun, J Zhong, V Motta… - Environmental and …, 2014 - Wiley Online Library
There is compelling evidence that particulate matter (PM) increases lung cancer risk by
triggering systemic inflammation, and leukocyte DNA hypomethylation. However, previous …

Micronucleus formation, DNA damage and repair in premenopausal women chronically exposed to high level of indoor air pollution from biomass fuel use in rural …

NK Mondal, B Mukherjee, D Das, MR Ray - Mutation Research/Genetic …, 2010 - Elsevier
Genotoxicity of indoor air pollution from biomass fuel use has been examined in 132
biomass users (median age 34 years) and 85 age-matched control women from eastern …

Neutrophils and respiratory tract DNA damage and mutagenesis: a review

AM Knaapen, N Güngör, RPF Schins, PJA Borm… - …, 2006 - academic.oup.com
Inflammation has been recognized as an important factor in cancer development. For the
lung, experimental studies with rats, as well as molecular epidemiological studies in …

Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC

N Holcomb, M Goswami, SG Han, T Scott, J D'Orazio… - DNA repair, 2017 - Elsevier
Chronic exposure to arsenic, most often through contaminated drinking water, has been
linked to several types of cancer in humans, including skin and lung cancer. However, the …

Personal Exposure to PM2.5 and Biomarkers of DNA Damage

M Sørensen, H Autrup, O Hertel, H Wallin… - … Biomarkers & Prevention, 2003 - AACR
Ambient particulate air pollution assessed as outdoor concentrations of particulate matter≤
2.5 μm in diameter (PM2. 5) has been associated with an increased cancer risk. However …

Mutagenic nitroarenes, diesel emissions, particulate-induced mutations and cancer: an essay on cancer-causation by a moving target

HS Rosenkranz - Mutation Research/Genetic Toxicology, 1996 - Elsevier
Initial analyses of the lung tumors seen in rats exposed for their lifetime to elevated levels of
the emissions of diesel engines suggested that they were due to powerful mutagens and …