Functional genetic analysis of mutations implicated in a human speech and language disorder
Mutations in the FOXP2 gene cause a severe communication disorder involving speech
deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments in …
deficits (developmental verbal dyspraxia), accompanied by wide-ranging impairments in …
Foxp1 regulation of neonatal vocalizations via cortical development
The molecular mechanisms driving brain development at risk in autism spectrum disorders
(ASDs) remain mostly unknown. Previous studies have implicated the transcription factor …
(ASDs) remain mostly unknown. Previous studies have implicated the transcription factor …
Birdsong decreases protein levels of FoxP2, a molecule required for human speech
Cognitive and motor deficits associated with language and speech are seen in humans
harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are …
harboring FOXP2 mutations. The neural bases for FOXP2 mutation-related deficits are …
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits
M Groszer, DA Keays, RMJ Deacon, JP De Bono… - Current Biology, 2008 - cell.com
The most well-described example of an inherited speech and language disorder is that
observed in the multigenerational KE family, caused by a heterozygous missense mutation …
observed in the multigenerational KE family, caused by a heterozygous missense mutation …
Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language
In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as
the basis of an inherited speech and language disorder suffered by members of the family …
the basis of an inherited speech and language disorder suffered by members of the family …
Common Genetic Variants in FOXP2 Are Not Associated with Individual Differences in Language Development
KL Mueller, JC Murray, JJ Michaelson… - PLoS …, 2016 - journals.plos.org
Much of our current knowledge regarding the association of FOXP2 with speech and
language development comes from singleton and small family studies where a small …
language development comes from singleton and small family studies where a small …
Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder
E Sollis, SA Graham, A Vino, H Froehlich… - Human molecular …, 2016 - academic.oup.com
De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …
Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression
Genetic studies have associated FOXP2 variation with speech and language disorders and
other neurodevelopmental disorders (NDDs) involving pathology of the cortex. In this brain …
other neurodevelopmental disorders (NDDs) involving pathology of the cortex. In this brain …
FOXP transcription factors in vertebrate brain development, function, and disorders
M Co, AG Anderson, G Konopka - Wiley Interdisciplinary …, 2020 - Wiley Online Library
FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …
development of several organ systems in the vertebrate body. Association of their genes …
De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment
Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have
been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 …
been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 …