Genetic disruptions of the forkhead box transcription factor FOXP2 in humans cause an
autosomal-dominant speech and language disorder. While FOXP2 expression pattern are …

Cortico-basal ganglia circuits are critical for speech and language and are implicated in
autism spectrum disorder, in which language function can be severely affected. We …

Neurodevelopmental disorders that disturb speech and language are highly heritable.
Isolation of the underlying genetic risk factors has been hampered by complexity of the …

Background Heterozygous disruptions of FOXP2 were the first identified molecular cause for
severe speech disorder: childhood apraxia of speech (CAS), and yet few cases have been …

Foxp subfamily genes were recently recognized to be members of the Fox gene family. Foxp
subfamily members contain a zinc finger domain and a leucine zipper motif in addition to a …

A significant proportion of children have unexplained problems acquiring proficient linguistic
skills despite adequate intelligence and opportunity. Developmental language disorders are …

The expression patterns of the transcription factor FOXP2 in the developing mammalian
forebrain have been described, and some studies have tested the role of this protein in the …

Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …

Recent advances have been made in the genetics of two human communication skills:
speaking and reading. Mutations of the FOXP2 gene cause a severe form of language …

FOXP2 was the first gene shown to cause a Mendelian form of speech and language
disorder. Although developmentally expressed in many organs, loss of a single copy of …