Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive
impairments, which have significant impacts on patients, families, and society. Currently …

Secondary brain injury after intracerebral hemorrhage (ICH) is the main cause of poor
prognosis in ICH patients, but the underlying mechanisms remain less known. The …

Stroke is associated with high mortality and extremely high disability rate. Regulating
ferroptosis seems to be a promising way to treat ischemic stroke. After stroke, vasogenic …

Abstract Objective We investigated whether Piezo1 could regulate oxygen-glucose
deprivation/reoxygenation injury of neurons through Ca 2+/calpain signaling. Methods …

Background Brain injury after intracerebral hemorrhage is extremely complicated, and the
exact mechanism remains puzzling. Piezo1, a novel mammalian mechanosensitive ion …

Abstract Phosphoinositide 3-kinase γ (PI3Kγ) expressed in immune cells is linked to
neuroinflammation in several neurological diseases. However, the expression and role of …

Piezo1 is a mechanically-gated calcium channel. Recent studies have shown that Piezo1, a
mechanically-gated calcium channel, can attenuate both psychosine-and …

Background The brain is a highly mechanosensitive organ, and changes in the mechanical
properties of brain tissue influence many physiological and pathological processes. Piezo …

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which
range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic …

Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular
mechanical cues to intracellular molecular signaling cascades through a process termed …