Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

The chronic mild stress (CMS) model of depression has high validity but has in the past
been criticized for being difficult to replicate. However, a large number of recent publications …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

The chronic mild stress (CMS) model of depression is considered by many to be the animal
model of depression that has the greatest validity and translational potential, but it has often …

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Major depressive disorder (MDD) is a severe illness imposing an increasing social and
economic burden worldwide. Numerous rodent models have been developed to investigate …

Major depressive disorder is a serious mental disorder that profoundly affects an individual's
quality of life. Although the aetiologies underlying this disorder remain unclear, an …

Rationale Major depression is a chronic disabling disorder, often preceded by stress.
Despite emerging clinical interest in mechanisms perpetuating episodes of depression …

This paper evaluates the validity, reliability and utility of the chronic mild stress (CMS) model
of depression. In the CMS model, rats or mice are exposed sequentially, over a period of …

Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …