Tetrahydroisoquinolines present in the mammalian brain, 1, 2, 3, 4-tetrahydroisoquinoline
(TIQ) and salsolinol, suspected to cause neurodegeneration leading to Parkinson's disease …

Endogenous tetrahydroisoquinolines, such as 1, 2, 3, 4-tetrahydroisoquinoline (TIQ) and 1-
methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (salsolinol), were tested for their …

Immediate behavioral and biochemical effects of single doses of 1, 2, 3, 4-
tetrahydroisoquinoline (TIQ, 50 mg/kg) and salsolinol (100 mg/kg), suspected of involvement …

Dopamine-derived 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (salsolinol, Sal)
and related compounds were examined for their selective neurotoxicity to dopamine …

The finding that endogenous tetrahydroisoquinolines may be involved in the etiology of
Parkinson's disease suggests that their administration may cause changes resembling those …

Abstract The TIQ derivatives 2-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (2-
MDTIQ) and 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (1-MDTIQ, salsolinol) …

Repeated amphetamine administration to rats under chronic ethanol intoxication resulted in
the formation of 1, 3‐dimethyl‐1, 2, 3, 4‐tetrahydroisoquinoline (1, 3‐DiMeTIQ), a novel …

The effect of chronic administration of a probable endogenous dopaminergic neurotoxin,
tetrahydroisoquinoline, has been examined on squirrel monkeys. Chronically administered …

The effect of single and multiple 1‐methyl‐1, 2, 3, 4‐tetrahydroisoquinoline (1MeTIQ) and 1‐
benzyl‐1, 2, 3, 4‐tetrahydroisoquinoline (1BnTIQ) administration on concentrations of …

Abstract The 1, 2, 3, 4-tetrahydroisoquinolines (TIQs) are compounds frequently described
as alkaloids that can be found in the human body fluids and/or tissues including the brain. In …