The Synaptic Properties of Some Tetrahydroisoquinoline Alkaloids Page 1 The Synaptic
Properties of Some Tetrahydroisoquinoline Alkaloids Gerald Cohen, Ph.D. The ability of TlQs to …

Abstract The compounds 1, 2, 3, 4-tetrahydroisoquinoline (TIQ) and 1-methyl-1, 2, 3, 4-
tetrahydroisoquinoline (1-MeTIQ) are endogenous in humans [18] and rats [9]. Whereas TIQ …

Direct evidence for accumulation of 1, 2, 3, 4-tetrahydroisoquinoline (TIQ), an endo-and
exogenous substance suspected of producing Parkinsonism in humans, has not yet been …

The in vivo effects of dopamine-derived alkaloids, 6, 7-dihydroxy-1, 2, 3, 4-
tetrahydroisoquinolines, salsolinols, and their N-methylated derivatives on a dopaminergic …

After the discovery of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), endogenous
and exogenous compounds have been intensively studied as pathogenic neurotoxins to …

Several members of the tetrahydroisoquinoline (TIQ) family of monoamine alkaloids can be
formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis …

The specific topic,“Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants–
New Perspectives In ParkinsonS Disease Therapy,” was chosen in light of accumulating …

Several derivatives of tetrahydroisoquinoline were injected bilaterally into the nucleus
accumbens of rat 2 h after a nialamide pretreatment and activity recorded in cages fitted with …

Methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ) is an endogenous compound that is
constantly present in the brain, and that exhibits neuroprotective activity. Our earlier study …

We carried out behavioral, pathological, and biochemical studies in order to determine
whether the stereo-structure of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline (1-MeTIQ) affects …