Polymer–Ionic liquid–Pharmaceutical conjugates as drug delivery systems

M Halayqa, M Zawadzki, U Domańska… - Journal of Molecular …, 2019 - Elsevier
Synthesis of a novel drug delivery system based on active pharmaceutical ingredient (API),
ammonium ionic liquid (IL) and grafted–Poly (l-lactide)(API-IL-LA) is presented. Sparingly …

API-ammonium ionic liquid–Polymer compounds as a potential tool for delivery systems

M Halayqa, M Zawadzki, U Domańska… - Journal of Molecular …, 2017 - Elsevier
The objective of the present study was to synthesized a novel drug delivery system based on
ammonium ionic liquid containing active pharmaceutical ingredients (API) grafted–Poly (L …

Ionic liquid-polymer nanoparticle hybrid systems as new tools to deliver poorly soluble drugs

A Júlio, R Caparica, SA Costa Lima, AS Fernandes… - Nanomaterials, 2019 - mdpi.com
The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs
into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work …

Pharmaceutical Functionalization of Monomeric Ionic Liquid for the Preparation of Ionic Graft Polymer Conjugates

A Mazur, K Niesyto, D Neugebauer - International Journal of Molecular …, 2022 - mdpi.com
Polymerizable choline-based ionic liquid (IL), ie,[2-(methacryloyloxy) ethyl]-
trimethylammonium (TMAMA/Cl¯), was functionalized by an ion exchange reaction with …

Choline supported poly (ionic liquid) graft copolymers as novel delivery systems of anionic pharmaceuticals for anti-inflammatory and anti-coagulant therapy

R Bielas, A Mielańczyk, M Skonieczna, Ł Mielańczyk… - Scientific reports, 2019 - nature.com
New type of carriers based on grafted poly (ionic liquid) s was designed for delivery of
ionically attached salicylates (Sal). Choline derived ionic liquid monomeric units were …

Development of ionic liquid-polymer nanoparticle hybrid systems for delivery of poorly soluble drugs

A Júlio, SAC Lima, S Reis, TS de Almeida… - Journal of Drug Delivery …, 2020 - Elsevier
The low solubility and permeability of drugs are two major challenges in the development of
delivery systems, thus the aim of this work was to develop ionic liquid-nanocarrier hybrid …

Ionic liquids in drug delivery

SN Pedro, CSR Freire, AJD Silvestre, MG Freire - Encyclopedia, 2021 - mdpi.com
Definition Ionic liquids (ILs) are molten salts composed of a large organic cation and an
organic/inorganic anion. Due to their ionic character, most ILs present advantageous …

Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids

A Gamboa, N Schüßler, E Soto-Bustamante… - European Journal of …, 2020 - Elsevier
New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-
drug conjugates are taking great relevance in the pharmaceutical industry due to their …

Linear copolymers based on choline ionic liquid carrying anti-tuberculosis drugs: Influence of anion type on physicochemical properties and drug release

K Niesyto, D Neugebauer - International Journal of Molecular Sciences, 2020 - mdpi.com
In this study, drug nanocarriers were designed using linear copolymers with different
contents of cholinium-based ionic liquid units, ie,[2-(methacryloyloxy) ethyl] …

Ionic liquids as active pharmaceutical ingredients (APIs)

RM Moshikur, M Goto - Application of ionic liquids in drug delivery, 2021 - Springer
The development of effective drug delivery systems for poorly water-soluble drugs remains a
significant challenge for the pharmaceutical industry because of their limited solubility …