Acupuncture activates ERK‐CREB pathway in rats exposed to chronic unpredictable mild stress

J Lu, J Liang, JR Wang, L Hu, Y Tu… - Evidence‐Based …, 2013 - Wiley Online Library
Extracellular signal‐regulated kinase (ERK)‐cAMP response element binding protein
(CREB) signal pathway has been implicated in the pathogenesis of depression. There is …

Antidepressant-like effects of acupuncture involved the ERK signaling pathway in rats

X Zhang, Y Song, T Bao, M Yu, M Xu, Y Guo… - … and Alternative Medicine, 2016 - Springer
Background The extracellular signal-regulated kinase (ERK) signaling pathway is
considered to be associated with the pathogenesis and treatment of depression …

Mechanisms underlying the antidepressant response of acupuncture via PKA/CREB signaling pathway

H Jiang, X Zhang, Y Wang, H Zhang, J Li… - Neural …, 2017 - Wiley Online Library
Protein kinase A (PKA)/cAMP response element‐binding (CREB) protein signaling pathway,
contributing to impaired neurogenesis parallel to depressive‐like behaviors, has been …

The role of MAPK and dopaminergic synapse signaling pathways in antidepressant effect of electroacupuncture pretreatment in chronic restraint stress rats

X Yang, Z Guo, J Lu, B Zhao, Y Fei, J Li… - Evidence‐Based …, 2017 - Wiley Online Library
Acupuncture has demonstrated the function in ameliorating depressive‐like behaviors via
modulating PKA/CREB signaling pathway. To further confirm the antidepressant mechanism …

Effects of electroacupuncture on chronic unpredictable mild stress rats depression‐like behavior and expression of p‐ERK/ERK and p‐P38/P38

J Xu, Y She, N Su, R Zhang, L Lao… - … and Alternative Medicine, 2015 - Wiley Online Library
We investigate the antidepressant‐like effect and mechanism of electroacupuncture (EA) on
a chronic unpredictable mild stress rats depression‐like behavior. In our study, depression …

Electroacupuncture relieves depression-like symptoms in rats exposed to chronic unpredictable mild stress by activating ERK signaling pathway

W Li, Y Zhu, SM Saud, Q Guo, S Xi, B Jia, S Jiao… - Neuroscience …, 2017 - Elsevier
Electroacupuncture (EA) has been shown to alleviate the symptoms associated with major
depressive disorder; however, the underlying mechanisms remain unclear. While the …

Effects of acupuncture on chronic stress-induced depression-like behavior and its central neural mechanism

MJ Lee, JS Ryu, SK Won, U Namgung, J Jung… - Frontiers in …, 2019 - frontiersin.org
Depression is a serious psychiatric disorder with an enormous socioeconomic burden, and it
is commonly comorbid with pain, chronic fatigue, or other inflammatory diseases. Recent …

Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway

L Bai, D Zhang, TT Cui, JF Li, YY Gao… - Frontiers in Behavioral …, 2020 - frontiersin.org
The CaMK pathway has been proven to play an important role in regulating cognitive
function and emotional response. Acupuncture through the CaMK pathway improves …

Acupuncture ameliorates depression-like behaviors through modulating the neuroinflammation mediated by TLR4 signaling pathway in rats exposed to chronic …

H Jiang, X Long, Y Wang, X Zhang, L Chen… - Molecular …, 2024 - Springer
Recently, emerging evidence has identified that stress-induced activation of
neuroinflammation is considered to be one of the most prevalently precipitating factors in the …

Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress

X Qi, W Lin, J Li, H Li, W Wang, D Wang, M Sun - Neurobiology of disease, 2008 - Elsevier
Our previous research indicates that the extracellular signal-regulated kinase (ERK)-cyclic
AMP-responsive-element-binding protein (CREB) signal system may be involved in the …