Therapeutic targeting of cellular stress to prevent cardiovascular disease: a review of the evidence

AD Mooradian - American Journal of Cardiovascular Drugs, 2017 - Springer
The availability of effective drugs targeting the major risk factors of cardiovascular disease
(CVD) has reduced morbidity and mortality. Cumulative relative risk of CVD events can be …

Endoplasmic reticulum stress: a common pharmacologic target of cardioprotective drugs

AD Mooradian, MJ Haas - European Journal of Pharmacology, 2022 - Elsevier
Despite the advances made in cardiovascular disease prevention, there is still substantial
residual risk of adverse cardiovascular events. Contemporary evidence suggests that …

[HTML][HTML] Cell signalling pathways leading to novel therapeutic strategies in cardiovascular disease

SG Shaw, DJ Abraham, DM Baker… - Cardiology research and …, 2012 - ncbi.nlm.nih.gov
Cardiovascular disease is a leading cause of morbidity and mortality with considerable
financial impact worldwide. This special issue explores recent developments and novel …

[PDF][PDF] Stress as a risk factor for cardiovascular events

G Mercanoglu, C Macit, F Mercanoglu - Cardiol Pharmacol, 2015 - academia.edu
Almost eight decades passed after the irst deinition of the term “stress”. In 1936 Hans Selye
deined this term as “the nonspeciic response of the body to any demand for change” which …

Oxidative stress in cardiovascular disease: a new avenue toward future therapeutic approaches

R Inagi - Recent Patents on Cardiovascular Drug Discovery …, 2006 - ingentaconnect.com
Oxidative stress is a common denominator in many aspects of the pathogenesis of
atherosclerosis and cardiovascular diseases. Some drugs, such as vitamin C, vitamin E, and …

Cardioprotective antihyperglycemic drugs ameliorate endoplasmic reticulum stress

AD Mooradian, MJ Haas - American Journal of Physiology …, 2024 - journals.physiology.org
Cellular stress, notably oxidative, inflammatory, and endoplasmic reticulum (ER) stress, is
implicated in the pathogenesis of cardiovascular disease. Modifiable risk factors for …

Pathological implications of cellular stress in cardiovascular diseases

T Ulaganathan, S Perales, S Mani… - The international journal …, 2023 - Elsevier
Cellular stress has been a key factor in the development of cardiovascular diseases. Major
types of cellular stress such as mitochondrial stress, endoplasmic reticulum stress, hypoxia …

Stressing out stem cells: linking stress and hematopoiesis in cardiovascular disease

RN Hanna, CC Hedrick - Nature medicine, 2014 - nature.com
Stress has long been thought to be a major contributing factor to cardiovascular disease,
although little is known about the underlying cellular mechanisms. A new study in humans …

[HTML][HTML] Chronic stress impacts the cardiovascular system: animal models and clinical outcomes

S Golbidi, JC Frisbee, I Laher - American Journal of …, 2015 - journals.physiology.org
Psychological stresses are associated with cardiovascular diseases to the extent that
cardiovascular diseases are among the most important group of psychosomatic diseases …

[图书][B] Stress and cardiovascular disease

P Hjemdahl, A Rosengren, A Steptoe - 2011 - books.google.com
The main aim of this book is to evaluate the concept of stress and provide tools for
physicians to identify patients who might benefit from stress management. This will …