PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins

JM Jones, JC Morrell, SJ Gould - The Journal of cell biology, 2004 - rupress.org
Integral peroxisomal membrane proteins (PMPs) are synthesized in the cytoplasm and
imported posttranslationally. Here, we demonstrate that PEX19 binds and stabilizes newly …

[PDF][PDF] Peroxisome membrane biogenesis: the stage is set

W Schliebs, WH Kunau - Current biology, 2004 - cell.com
Pex3p and Pex19p are key players in the post-translational import of peroxisomal
membrane proteins. New data suggest that these peroxins act in tandem, Pex19p as a …

Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis

M Fransen, I Vastiau, C Brees, V Brys… - Journal of molecular …, 2005 - Elsevier
Pex19p, a primarily cytosolic protein, is essential for the biogenesis of numerous
peroxisomal membrane proteins (PMPs); however, its precise function is unclear. Pex19p …

The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions

RLM Jansen, IJ van der Klei - FEBS letters, 2019 - Wiley Online Library
The peroxisomal membrane protein (PMP) Pex3 and its cytosolic interaction partner Pex19
have been implicated in peroxisomal membrane biogenesis. Although these peroxins have …

Insertion of Pex5p into the peroxisomal membrane is cargo protein-dependent

AM Gouveia, CP Guimarães, ME Oliveira… - Journal of Biological …, 2003 - ASBMB
It is now generally accepted that Pex5p, the receptor for most peroxisomal matrix proteins,
cycles between the cytosol and the peroxisomal compartment. According to current models …

A new yeast peroxin, Pex36, a functional homolog of mammalian PEX16, functions in the ER-to-peroxisome traffic of peroxisomal membrane proteins

JC Farré, K Carolino, V Stasyk, OG Stasyk… - Journal of molecular …, 2017 - Elsevier
Peroxisomal membrane proteins (PMPs) traffic to peroxisomes by two mechanisms: direct
insertion from the cytosol into the peroxisomal membrane and indirect trafficking to …

Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals

H Rottensteiner, A Kramer, S Lorenzen… - Molecular biology of …, 2004 - Am Soc Cell Biol
Targeting of peroxisomal membrane proteins (PMPs) is a multistep process that requires not
only recognition of PMPs in the cytosol but also their insertion into the peroxisomal …

PEX14 is required for microtubule-based peroxisome motility in human cells

P Bharti, W Schliebs, T Schievelbusch… - Journal of cell …, 2011 - journals.biologists.com
We have established a procedure for isolating native peroxisomal membrane protein
complexes from cultured human cells. Protein-A-tagged peroxin 14 (PEX14), a central …

Pex18p is constitutively degraded during peroxisome biogenesis

PE Purdue, PB Lazarow - Journal of Biological Chemistry, 2001 - ASBMB
Pex18p and Pex21p are structurally related yeast peroxins (proteins required for
peroxisome biogenesis) that are partially redundant in function. One or the other is essential …

Cytosolic factors mediate protein insertion into the peroxisomal membrane

B Pause, P Diestelkötter, H Heid, WW Just - FEBS letters, 1997 - Wiley Online Library
Following in vitro translation of the 22 kDa peroxisomal membrane protein (Pmp22p), gel
filtration analysis of the post‐ribosomal supernatant revealed that Pmp22p forms two …