In many human infections, hosts and pathogens coexist for years or decades. Important
examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception …

Most patients with the genetic disease cystic fibrosis (CF) succumb to chronic airway
infection caused by the bacterium Pseudomonas aeruginosa. CF lung disease follows a …

ABSTRACT The Gram-negative bacterium Pseudomonas aeruginosa is a common cause of
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …

Pseudomonas aeruginosa is an opportunistic pathogen of humans and is a major cause of
morbidity and mortality in patients with cystic fibrosis (CF). Prolonged infection of the …

Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Strains of Pseudomonas aeruginosa, isolated from the sputum of relatively fit patients with
cystic fibrosis (CF) who had been recently colonized by the organism, showed typical …

The epidemiology of chronic colonization of airways with Pseudomonas aeruginosa was
monitored in 44 patients with cystic fibrosis (CF) by Dra I/Spe I macrorestriction analyses of …

One of the hallmarks of the Gram-negative bacterium Pseudomonas aeruginosa is its ability
to thrive in diverse environments that includes humans with a variety of debilitating diseases …

Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa
is often accompanied by a reduction in bacterial growth rate. This reduction has been …

Little is known about how within-host evolution compares between genotypically different
strains of the same pathogenic species. We sequenced the whole genomes of 474 …