A rapid and sensitive radioimmunoassay for digoxin is described, which is capable of
detecting as little as 25 μμg of digoxin. This assay, requiring as little as 0.1 ml of serum or …

During 1966 to 1968, 64 of 459 (13.9%) prospectively monitored, digoxin‐treated patients at
Massachusetts General Hospital suffered adverse reactions to the drug. Measurements of …

The ability to precisely predict serum digoxin concentrations using 12 published methods in
a group of 85 patients was undertaken. Two methods of estimating creatinine clearance and …

Thirty-four dogs were given tritium-labeled digoxin intravenously. Serum and tissue
concentrations and half-times were determined. As demonstrated previously in human …

Methods During the period of July, 1971, to June, 1973, the serum digoxin concentration
was determined in Over 1,200 patients admitted to the University of Kansas Medical Center …

Serum and myocardial digoxin levels were studied in 18 patients who came to autopsy. An
independent analysis of electrocardiograms prior to death was made to ascertain the …

Background Serum digoxin concentrations (SDCs) are frequently sampled before
completion of drug distribution. If elevated, these concentrations may be misinterpreted …

No significant differences were found between plasma digoxin concentrations in samples
assayed by both radioimmunoassay and 86 Rb uptake. The mean plasma digoxin …

Plasma digoxin levels were determined in 6 healthy, young male subjects by
radioimmunoassay. All were given an oral dose of 1.0 mg. of digoxin the first day, followed …

Factors influencing serum digoxin concentrations, and the relation of these levels to
classical electrocardiographic (ECG) and clinical manifestations of toxicity, were assessed in …