As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …

The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

Inflammasomes continue to generate interest in an increasing number of disciplines owing
to their unique ability to integrate a myriad of signals from pathogen‐and damage …

The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …

Inflammasomes are large protein complexes that trigger host defense in cells by activating
inflammatory caspases for cytokine maturation and pyroptosis. NLRP6 is a sensor protein in …

Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation
and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

The inflammasome is an intracellular multimolecular complex that controls caspase-1
activity in the innate immune system. NLRP3, a member of the NLR family of cytosolic …