[PDF][PDF] Investigating pain in Parkinson's disease and unravelling the underlying mechanisms

YB Buhidma - 2022 - kclpure.kcl.ac.uk
Pain is a key non-motor feature of Parkinson's disease (PD) that significantly impacts on the
quality of life of people with this condition. The mechanisms underlying chronic pain in PD …

[引用][C] Characterizing Pain in Parkinson's Disease: Unveiling Types and Underlying Pathophysiology through a Scoping Review

D Desai, S Desai - Parkinsonism & Related Disorders, 2024 - prd-journal.com
Background: Pain, a pervasive and disabling aspect of Parkinson's disease (PD),
necessitates a comprehensive understanding of its types and the intricate mechanisms …

Periaqueductal grey and spinal cord pathology contribute to pain in Parkinson's disease

Y Buhidma, C Hobbs, M Malcangio, S Duty - npj Parkinson's Disease, 2023 - nature.com
Pain is a key non-motor feature of Parkinson's disease (PD) that significantly impacts on life
quality. The mechanisms underlying chronic pain in PD are poorly understood, hence the …

Potential of animal models for advancing the understanding and treatment of pain in Parkinson's disease

Y Buhidma, K Rukavina, KR Chaudhuri… - NPJ Parkinson's disease, 2020 - nature.com
Pain is a commonly occurring non-motor symptom of Parkinson's disease (PD). Treatment of
pain in PD remains less than optimal and a better understanding of the underlying …

Cellular and synaptic mechanisms for Parkinson's disease-related chronic pain

JS Lu, QY Chen, X Chen, XH Li, Z Zhou, Q Liu… - Molecular …, 2021 - journals.sagepub.com
Parkinson's disease is the second most common neurodegenerative disorder after
Alzheimer's disease. Chronic pain is experienced by the vast majority of patients living with …

Altered parabrachial nucleus nociceptive processing may underlie central pain in Parkinson's disease

A Pautrat, R Al Tannir, K Pernet-Gallay… - npj Parkinson's …, 2023 - nature.com
The presence of central neuropathic pain in Parkinson's disease suggests that the brain
circuits that allow us to process pain could be dysfunctional in the disorder. However, there …

Pain in Parkinson's disease: a neuroanatomy-based approach

D Nardelli, F Gambioli, MI De Bartolo… - Brain …, 2024 - academic.oup.com
Parkinson's Disease is a progressive neurodegenerative disorder characterized by the
deposition of misfolded alpha-synuclein in different regions of the central and peripheral …

The hidden side of Parkinson's disease: Studying pain, anxiety and depression in animal models

F Faivre, A Joshi, E Bezard, M Barrot - Neuroscience & Biobehavioral …, 2019 - Elsevier
Parkinson's disease is a neurodegenerative disease leading to the loss of midbrain
dopamine neurons. It is well known and characterized by motor symptoms that are …

Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's Disease via GABAergic Pathway

X Zhuang, Y Chen, X Zhuang, T Chen, T Xing… - Frontiers in …, 2016 - frontiersin.org
Background/aims Hypersensitive pain response is often observed in patients with
Parkinson's disease (PD); however, the mechanisms responsible for hyperalgesia are not …

[HTML][HTML] Pain in early-stage Parkinson's disease: Implications from clinical features to pathophysiology mechanisms

MT Tseng, CH Lin - Journal of the Formosan Medical Association, 2017 - Elsevier
Pain is a common non-motor symptom of Parkinson's disease (PD) that markedly impacts
patients' quality of life. Although pain occurs mostly secondary to motor disability of PD, pain …