A designed photoenzyme for enantioselective [2+ 2] cycloadditions
JS Trimble, R Crawshaw, FJ Hardy, CW Levy… - Nature, 2022 - nature.com
The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …
enzyme families with functions beyond those found in nature. To this end, genetic code …
Enantioselective [2+ 2]-cycloadditions with triplet photoenzymes
N Sun, J Huang, J Qian, TP Zhou, J Guo, L Tang… - Nature, 2022 - nature.com
Naturally evolved enzymes, despite their astonishingly large variety and functional diversity,
operate predominantly through thermochemical activation. Integrating prominent …
operate predominantly through thermochemical activation. Integrating prominent …
A dual-catalysis approach to enantioselective [2+ 2] photocycloadditions using visible light
J Du, KL Skubi, DM Schultz, TP Yoon - Science, 2014 - science.org
In contrast to the wealth of catalytic systems that are available to control the stereochemistry
of thermally promoted cycloadditions, few similarly effective methods exist for the …
of thermally promoted cycloadditions, few similarly effective methods exist for the …
Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis
Living organisms rely on simultaneous reactions catalysed by mutually compatible and
selective enzymes to synthesize complex natural products and other metabolites. To …
selective enzymes to synthesize complex natural products and other metabolites. To …
Enhancing the potential of enantioselective organocatalysis with light
M Silvi, P Melchiorre - Nature, 2018 - nature.com
Organocatalysis—catalysis mediated by small chiral organic molecules—is a powerful
technology for enantioselective synthesis, and has extensive applications in traditional ionic …
technology for enantioselective synthesis, and has extensive applications in traditional ionic …
Unveiling the impact of the light source and steric factors on [2+ 2] heterocycloaddition reactions
Abstract Information gained from in-depth mechanistic investigations can be used to control
the selectivity of reactions, leading to expansion of the generality of synthetic processes and …
the selectivity of reactions, leading to expansion of the generality of synthetic processes and …
Photoenzymatic enantioselective intermolecular radical hydroalkylation
Enzymes are increasingly explored for use in asymmetric synthesis,–, but their applications
are generally limited by the reactions available to naturally occurring enzymes. Recently …
are generally limited by the reactions available to naturally occurring enzymes. Recently …
A cyclase that catalyses competing 2+ 2 and 4+ 2 cycloadditions
Cycloaddition reactions are among the most widely used reactions in chemical synthesis.
Nature achieves these cyclization reactions with a variety of enzymes, including Diels …
Nature achieves these cyclization reactions with a variety of enzymes, including Diels …
Light-enabled deracemization of cyclopropanes by Al-salen photocatalysis
C Onneken, T Morack, J Soika, O Sokolova… - Nature, 2023 - nature.com
Privileged chiral catalysts—those that share common structural features and are
enantioselective across a range of reactions—continue to transform the chemical-research …
enantioselective across a range of reactions—continue to transform the chemical-research …
Organocatalytic stereoselective [8+ 2] and [6+ 4] cycloadditions
R Mose, G Preegel, J Larsen, S Jakobsen… - Nature Chemistry, 2017 - nature.com
Cycloadditions that involve more than six π electrons are termed higher-order cycloadditions
and are an excellent tool for solving complex synthetic challenges, as they provide direct …
and are an excellent tool for solving complex synthetic challenges, as they provide direct …