The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …

Naturally evolved enzymes, despite their astonishingly large variety and functional diversity,
operate predominantly through thermochemical activation. Integrating prominent …

In contrast to the wealth of catalytic systems that are available to control the stereochemistry
of thermally promoted cycloadditions, few similarly effective methods exist for the …

Living organisms rely on simultaneous reactions catalysed by mutually compatible and
selective enzymes to synthesize complex natural products and other metabolites. To …

Organocatalysis—catalysis mediated by small chiral organic molecules—is a powerful
technology for enantioselective synthesis, and has extensive applications in traditional ionic …

Abstract Information gained from in-depth mechanistic investigations can be used to control
the selectivity of reactions, leading to expansion of the generality of synthetic processes and …

Enzymes are increasingly explored for use in asymmetric synthesis,–, but their applications
are generally limited by the reactions available to naturally occurring enzymes. Recently …

Cycloaddition reactions are among the most widely used reactions in chemical synthesis.
Nature achieves these cyclization reactions with a variety of enzymes, including Diels …

Privileged chiral catalysts—those that share common structural features and are
enantioselective across a range of reactions—continue to transform the chemical-research …

Cycloadditions that involve more than six π electrons are termed higher-order cycloadditions
and are an excellent tool for solving complex synthetic challenges, as they provide direct …