Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/42MAPK signaling
F Alimirah, T Pulido, A Valdovinos, S Alptekin, E Chang… - Cancer research, 2020 - AACR
Cellular senescence entails an irreversible growth arrest that evolved in part to prevent
cancer. Paradoxically, senescent cells secrete proinflammatory and growth-stimulatory …
cancer. Paradoxically, senescent cells secrete proinflammatory and growth-stimulatory …
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
A Freund, CK Patil, J Campisi - The EMBO journal, 2011 - embopress.org
Cellular senescence suppresses cancer by forcing potentially oncogenic cells into a
permanent cell cycle arrest. Senescent cells also secrete growth factors, proteases, and …
permanent cell cycle arrest. Senescent cells also secrete growth factors, proteases, and …
[HTML][HTML] The senescence-associated secretory phenotype: critical effector in skin cancer and aging
K Ghosh, BC Capell - Journal of Investigative Dermatology, 2016 - Elsevier
Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an
indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged …
indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged …
[HTML][HTML] Oncogene-induced senescence pathways weave an intricate tapestry
P Yaswen, J Campisi - Cell, 2007 - cell.com
The induction of cellular senescence by activated oncogenes acts as a barrier to cell
transformation. Now, Sun et al.(2007) identify a key component of a senescence pathway …
transformation. Now, Sun et al.(2007) identify a key component of a senescence pathway …
[HTML][HTML] Senescence and tumor suppression
P Hinds, J Pietruska - F1000Research, 2017 - ncbi.nlm.nih.gov
Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …
proliferation of cells at risk for malignant transformation. Although senescent cells have …
Cellular senescence: a link between cancer and age-related degenerative disease?
Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …
Cellular senescence and tumor promotion: Is aging the key?
N Loaiza, M Demaria - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2016 - Elsevier
The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …
irreversible growth arrest in response to potentially oncogenic signals to prevent the …
Context-dependent effects of cellular senescence in cancer development
P Lecot, F Alimirah, PY Desprez, J Campisi… - British journal of …, 2016 - nature.com
Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …
proliferation of premalignant cells. However, several lines of evidence show that senescent …
Senescent cells as a source of inflammatory factors for tumor progression
AR Davalos, JP Coppe, J Campisi… - Cancer and Metastasis …, 2010 - Springer
Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …
The senescence-associated secretory phenotype: the dark side of tumor suppression
JP Coppé, PY Desprez, A Krtolica… - Annual review of …, 2010 - annualreviews.org
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …
risk for malignant transformation. However, accumulating evidence shows that senescent …