Cellular senescence entails an irreversible growth arrest that evolved in part to prevent
cancer. Paradoxically, senescent cells secrete proinflammatory and growth-stimulatory …

Cellular senescence suppresses cancer by forcing potentially oncogenic cells into a
permanent cell cycle arrest. Senescent cells also secrete growth factors, proteases, and …

Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an
indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged …

The induction of cellular senescence by activated oncogenes acts as a barrier to cell
transformation. Now, Sun et al.(2007) identify a key component of a senescence pathway …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …

The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …