Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK‐CDK5‐PPARγ Signaling

K Fang, M Gu - BioMed Research International, 2020 - Wiley Online Library
Crocin is a carotenoid compound which possesses multiple biological activities. Our and
other laboratory's previous findings show that crocin alleviates obesity and type 2 diabetes …

Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis

M Gu, L Luo, K Fang - Bioscience trends, 2018 - jstage.jst.go.jp
Obesity has become a severe public health problem worldwide. Crocin, a natural product,
has been reported to have a number of pharmacological activities, including …

[HTML][HTML] The effect of crocin supplementation on glycemic control, insulin resistance and active AMPK levels in patients with type 2 diabetes: a pilot study

V Behrouz, A Dastkhosh, M Hedayati… - Diabetology & metabolic …, 2020 - Springer
Background Crocin as a carotenoid exerts anti-oxidant, anti-inflammatory, anti-cancer,
neuroprotective and cardioprotective effects. Besides, the increasing prevalence of diabetes …

[HTML][HTML] Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK

MM Algandaby - Saudi Journal of Biological Sciences, 2020 - Elsevier
Metabolic syndrome (Mets) is a major health hazard. The syndrome is strongly linked to
cardiovascular disease. The objective of the current study was to address whether or not …

[HTML][HTML] Modulating effects of crocin on lipids and lipoproteins: Mechanisms and potential benefits

H Yaribeygi, M Maleki, F Rashid-Farrokhi… - Heliyon, 2024 - cell.com
Dyslipidemia poses a significant risk to cardiovascular health in both diabetic and non-
diabetic individuals. Therefore, it is crucial to normalize lipid homeostasis in order to prevent …

Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats

L Xi, Z Qian, G Xu, S Zheng, S Sun, N Wen… - The Journal of nutritional …, 2007 - Elsevier
Crocetin, a unique carotenoid with potent antioxidative and anti-inflammatory activities, is a
major ingredient of saffron which is used as an important spice and food colorant in various …

[HTML][HTML] Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice

L Luo, K Fang, X Dan, M Gu - Lipids in health and disease, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity, type 2
diabetes and other metabolic disorders worldwide. Crocin is a carotenoid compound …

Crocin molecular signaling pathways at a glance: A comprehensive review

M Boozari, H Hosseinzadeh - Phytotherapy Research, 2022 - Wiley Online Library
Crocin is a hydrophilic carotenoid that is synthesized in the flowers of the Crocus genus.
Numerous in vitro and in vivo research projects have been published about the biological …

Crocin attenuates oxidative stress and inflammation in myocardial infarction induced by isoprenaline via PPARγ activation in diabetic rats

M Badavi, SA Mard, M Dianat… - Journal of Diabetes & …, 2020 - Springer
Background and purpose Hyperglycemia induced oxidative stress and inflammation lead to
development of diabetic cardiomyopathy. Diabetic patients are more at risk for myocardial …

Inhibitory effect on protein kinase Cθ by Crocetin attenuates palmitate-induced insulin insensitivity in 3T3-L1 adipocytes

L Yang, Z Qian, H Ji, R Yang, Y Wang, L Xi… - European journal of …, 2010 - Elsevier
Epidemiologic and experimental studies have pointed to an etiologic role of elevated
plasma free fatty acids in insulin resistance, which is frequently associated with a state of low …