Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …
epigenetic modifications associated with elevated adiposity, including DNA methylation …
Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization …
Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …
the general population remains uncertain. Methods and Findings We conducted an …
Epigenome‐wide study identifies novel methylation loci associated with body mass index and waist circumference
Objective To conduct an epigenome‐wide analysis of DNA methylation and obesity traits.
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …
Body mass index drives changes in DNA methylation: a longitudinal study
Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study
S Sayols-Baixeras, I Subirana, A Fernández-Sanlés… - Epigenetics, 2017 - Taylor & Francis
Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …
Obesity is highly heritable but the genetic variants identified by genome-wide association …
Epigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood
Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …
blood that are able to mirror those in target tissues. Although some have suggested potential …
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
Background DNA methylation has been shown to be associated with adiposity in adulthood.
However, whether similar DNA methylation patterns are associated with childhood and …
However, whether similar DNA methylation patterns are associated with childhood and …
Adiposity is associated with DNA methylation profile in adipose tissue
Background: Adiposity is a risk factor for type 2 diabetes and cardiovascular disease,
suggesting an important role for adipose tissue in the development of these conditions. The …
suggesting an important role for adipose tissue in the development of these conditions. The …
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
S Voisin, MS Almén, GY Zheleznyakova, L Lundberg… - Genome medicine, 2015 - Springer
Background The mechanisms by which genetic variants, such as single nucleotide
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …