Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
ME Cockman, N Masson, DR Mole, P Jaakkola… - Journal of Biological …, 2000 - ASBMB
The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in
cellular responses to oxygen availability, being required for the oxygen-dependent …
cellular responses to oxygen availability, being required for the oxygen-dependent …
The VHL tumor suppressor and HIF: insights from genetic studies in mice
PP Kapitsinou, VH Haase - Cell Death & Differentiation, 2008 - nature.com
Abstract The von Hippel–Lindau tumor suppressor gene product, pVHL, functions as the
substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen …
substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen …
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
Abstract von Hippel–Lindau (VHL) disease is a hereditary cancer syndrome that is
characterized by the development of multiple vascular tumors and is caused by inactivation …
characterized by the development of multiple vascular tumors and is caused by inactivation …
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation
KJ Turner, JW Moore, A Jones, CF Taylor… - Cancer research, 2002 - AACR
Abstract The von Hippel-Lindau tumor suppressor protein acts as the substrate recognition
componentof a ubiquitin E3 ligase that targets hypoxia-inducible factor (HIF)-α subunits for …
componentof a ubiquitin E3 ligase that targets hypoxia-inducible factor (HIF)-α subunits for …
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
Abstract The von Hippel-Lindau tumour suppressor gene (VHL) targets hypoxia inducible
factor (HIF)-α subunits for ubiquitin dependent proteolysis. To better understand the role of …
factor (HIF)-α subunits for ubiquitin dependent proteolysis. To better understand the role of …
The von Hippel–Lindau tumor suppressor protein: new insights into oxygen sensing and cancer
W Kim, WG Kaelin Jr - Current opinion in genetics & development, 2003 - Elsevier
The von Hippel–Lindau tumor suppressor protein (pVHL) is the substrate-recognition
module of an E3 ubiquitin ligase that targets the alpha subunits of hypoxia-inducible factor …
module of an E3 ubiquitin ligase that targets the alpha subunits of hypoxia-inducible factor …
The von Hippel–Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis
CW Pugh, PJ Ratcliffe - Seminars in cancer biology, 2003 - Elsevier
Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor
protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights …
protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights …
[HTML][HTML] Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein
K Tanimoto, Y Makino, T Pereira, L Poellinger - The EMBO journal, 2000 - embopress.org
In normoxic cells the hypoxia‐inducible factor‐1α (HIF‐1α) is rapidly degraded by the
ubiquitin‐proteasome pathway, and activation of HIF‐1α to a functional form requires protein …
ubiquitin‐proteasome pathway, and activation of HIF‐1α to a functional form requires protein …
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
Inactivation of the von Hippel-Lindau (VHL) gene is associated with the development of
highly vascularized tumors. pVHL targets the α subunits of hypoxia inducible factor (HIF) for …
highly vascularized tumors. pVHL targets the α subunits of hypoxia inducible factor (HIF) for …
The von Hippel–Lindau tumor suppressor protein
M Ivan, WG Kaelin Jr - Current opinion in genetics & development, 2001 - Elsevier
The von Hippel–Lindau tumor suppressor protein (pVHL) has been shown to bind directly to
the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor) …
the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor) …