Biodistribution and magnetic resonance imaging of cross-linked DTPA polysaccharides

WA Gibby, J Billings, J Hall, TW Ovitt - Investigative Radiology, 1990 - journals.lww.com
Large polysaccharide complexes, cross-linked with DTPA and chelated with gadolinium
have been tested for various potential uses for magnetic resonance imaging (MRI) in rats …

MS-325: albumin-targeted contrast agent for MR angiography.

RB Lauffer, DJ Parmelee, SU Dunham, HS Ouellet… - Radiology, 1998 - pubs.rsna.org
PURPOSE: To evaluate the protein-binding and signal enhancement characteristics of MS-
325, a gadolinium-based magnetic resonance (MR) imaging blood pool agent that binds to …

PEG-g-poly(GdDTPA-co-l-cystine):  A Biodegradable Macromolecular Blood Pool Contrast Agent for MR Imaging

AM Mohs, X Wang, KC Goodrich, Y Zong… - Bioconjugate …, 2004 - ACS Publications
Biodegradable PEGylated Gd-DTPA l-cystine copolymers, PEG-g-poly (GdDTPA-co-l-
cystine), were prepared and tested as a blood pool contrast agent in mice. The …

Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging.

B Hamm, T Staks, A Mühler, M Bollow, M Taupitz… - Radiology, 1995 - pubs.rsna.org
PURPOSE: To determine the safety, pharmacokinetics, and magnetic resonance (MR)
imaging results of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB …

Synthesis and preliminary evaluation of MP‐2269: a novel, nonaromatic small‐molecule blood‐pool MR contrast agent

RA Wallace, JP Haar Jr, DB Miller… - Magnetic resonance …, 1998 - Wiley Online Library
A nonaromatic, small‐molecule, gadolinium (3+)‐chelate code named MP‐2269 was
synthesized and evaluated in animals as a potential MR contrast agent for blood pool. The …

Polyaspartamide gadolinium complexes containing sulfadiazine groups as potential macromolecular MRI contrast agents

GP Yan, ML Liu, LY Li - Bioconjugate chemistry, 2005 - ACS Publications
Both diethylenetriaminepentaacetic acid (DTPA) and sulfadiazine (SD) were incorporated
into polyaspartamides with different side chains, including poly-α, β-[N-(2-hydroxyethyl)-l …

In vivo imaging of extraction fraction of low molecular weight mr contrast agents and perfusion rate in rodent tumors

DA Kovar, MZ Lewis, JN River… - Magnetic resonance …, 1997 - Wiley Online Library
Tissue uptake of a fully extractable MR detectable tracer, deuterated water (D2O), was
compared with that of a less extractable contrast agent, Gadolinium‐DTPA‐dimeglumine …

Biliary excretion and pharmacokinetics of a gadolinium chelate used as a liver-specific contrast agent for magnetic resonance imaging in the rat

G Schuhmann-Giampieri, H Schitt-Willich… - Journal of …, 1993 - Elsevier
The introduction of a lipophilic moiety into the gadolinium chelate Gd-DTPA (dimeglumine
gadopentetate, Magnevist) yielded Gd-EOB-DTPA (short form), which has potential as a …

1H T1 and T2 measurements of the MR imaging contrast agents Gd-DTPA and Gd-DTPA BMA at 1.5 T

JR Reichenbach, T Hackländer, T Harth, M Hofer… - European …, 1997 - Springer
We report in vitro T 1 and T 2 relaxation studies for the open-chain complexes Gd-DTPA and
Gd-DTPA BMA. Measurements were performed on phantoms containing aqueous and …

A new lipophilic gadolinium chelate as a tissue‐specific contrast medium for MRI

HJ Weinmann, G Schuhmann‐Giampieri… - Magnetic resonance …, 1991 - Wiley Online Library
Abstract Gd‐Ethoxybenzyl‐DTPA (Gd‐EOB‐DTPA) is a highly water‐soluble paramagnetic
contrast agent. Due to its protein binding of about 10% and its lipophilic residue, Gd‐EOB …