Characterization of tumor angiogenesis with dynamic contrast‐enhanced MRI and biodegradable macromolecular contrast agents in mice

Y Feng, EK Jeong, AM Mohs… - … in Medicine: An …, 2008 - Wiley Online Library
The efficacy of polydisulfide‐based biodegradable macromolecular contrast agents for
characterizing tumor angiogenesis was investigated in a mouse model using dynamic …

Influence of human serum albumin on longitudinal and transverse relaxation rates (R1 and R2) of magnetic resonance contrast agents

FL Giesel, H von Tengg-Kobligk… - Investigative …, 2006 - journals.lww.com
Objectives: Exogenous magnetic resonance (MR) contrast media (CM) are used to improve
detection and delineation of physiological and pathologic structures. Temporary binding …

Tumor imaging with a macromolecular paramagnetic contrast agent: gadopentetate dimeglumine-polylysine

LR Opsahl, EE Uzgiris, DR Vera - Academic radiology, 1995 - Elsevier
RATIONALE AND OBJECTIVES.: We evaluated magnetic resonance (MR) contrast
enhancement of tumor tissue following injection of the macromolecular conjugate …

Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores

N Sato, H Kobayashi, A Hiraga, T Saga… - … in Medicine: An …, 2001 - Wiley Online Library
Four macromolecular contrast agents are synthesized to visualize small vessels by MRI
using generation‐3 (G3D),‐4 (G4D),‐5 (G5D), and‐6 (G6D) polyamidoamine dendrimers …

3D‐micro‐MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties

H Kobayashi, N Sato, A Hiraga, T Saga… - … in Medicine: An …, 2001 - Wiley Online Library
Four novel macromolecular MRI contrast agents, all of which had the same chemical
composition but different molecular weights, were prepared using generation‐3,‐4,‐5, and …

New macromolecular polymeric MRI contrast agents for application in the differentiation of cancer from benign soft tissues

CC Cyran, Y Fu, HJ Raatschen, V Rogut… - Journal of Magnetic …, 2008 - Wiley Online Library
Purpose To compare three new macromolecular polyethylene glycol (PEG)‐core
dendrimeric gadolinium (Gd)‐based MRI contrast agents for their applicability in quantitative …

Polyion complex micelle MRI contrast agents from poly (ethylene glycol)-b-poly (L-lysine) block copolymers having Gd-DOTA; preparations and their control of T1 …

K Shiraishi, K Kawano, Y Maitani… - Journal of controlled …, 2010 - Elsevier
The current study synthesized macromolecular magnetic resonance imaging (MRI) contrast
agents constituted of the poly (ethylene glycol)-b-poly (l-lysine) block copolymer (PEG-P …

[引用][C] Biodistribution and toxicity of MR imaging contrast media

AN Oksendal, PA Hals - Journal of Magnetic Resonance …, 1993 - Wiley Online Library
The clinical effect of an MR imaging contrast medium is determined not only by the contrast-
enhancing properties of the compound but also by its pharmacokinetic properties, which …

In vivo Characterization of Gd(BME‐DTTA), a myocardial MRI contrast agent: tissue distribution of its MRI intensity enhancement, and its effect on heart function

WJ Chu, T Simor, GA Elgavish - NMR in Biomedicine: An …, 1997 - Wiley Online Library
We have determined an LD50 of 0.56±0.05 mmol/kg for liposomal Gd (BME‐DTTA) in mice
and also shown that liposomal Gd (BME‐DTTA) has no deleterious effects on heart rate …

Gd‐DTPA‐polylysine—enhanced pulmonary time‐of‐flight MR angiography

JC Böck, U Pison, F Kaufmann… - Journal of Magnetic …, 1994 - Wiley Online Library
The enhancing effect of gadolinium diethylenetriam‐inepentaacetic acid (DTPA) polylysine
(a macromolecular paramagnetic contrast agent) in time‐of‐flight magnetic resonance (MR) …