Small ribozymes cleave their RNA phosphodiester backbone by catalyzing a
transphosphorylation reaction wherein a specific O2′ functions as the nucleophile. While …

It is becoming increasingly clear that RNA is more than a passive carrier of genetic
information. Folded RNA molecules play key roles in almost every aspect of cellular …

An unique catalytic strategy was recently reported for the glm S ribozyme [Bingaman et al.,
Nat. Chem. Biol. 2017, 13, 439− 445] that involves promotion of productive hydrogen …

Since the discovery of catalytic RNA molecules (ribozymes), intense research has been
devoted to understand their structure and activity. Among RNA molecules, the large …

The natural RNA enzymes catalyse phosphate-group transfer and peptide-bond formation.
Initially, metal ions were proposed to supply the chemical versatility that nucleotides lack. In …

Within the three-dimensional architectures of RNA molecules, divalent metal ions populate
specific locations, shedding their water molecules to form chelates. These interactions help …

Metal cations represent key elements of RNA structure and function. In the Neurospora VS
ribozyme, metal cations play diverse roles; they are important for substrate recognition …

Background: The catalytic activity of RNA enzymes is thought to require divalent metal ions,
which are believed to facilitate RNA folding and to play a direct chemical role in the reaction …

Ribonucleoprotein (RNP)‐machineries are comprised of intricate networks of long
noncoding RNAs and proteins that allow them to actively participate in transcription, RNA …

Naturally occurring RNA molecules exhibit many unexpected and fascinating properties in
living cells such as protein synthesis and transport, regulation of metabolic functions, and …