Abstract Type 1 diabetes (T1D) is a debilitating autoimmune disease that results from T-cell-
mediated destruction of insulin-producing β-cells. Its incidence has increased during the …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta
cells and incorporates genetic and environmental factors, including complex genetic …

Deletion of the innate immune adaptor myeloid differentiation primary response gene 88
(MyD88) in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D) results in …

Type 1 diabetes develops over many years and is characterized ultimately by the destruction
of insulin-producing pancreatic beta cells by autoreactive T cells. Nonetheless, the role of …

In recent years, several associations between common chronic human disorders and altered
gut microbiome composition and function have been reported,. In most of these reports …

Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese
diabetic (NOD) strain, we found that key features of disease correlated inversely with blood …

Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …

The composition of the gut microbiome represents a very important environmental factor that
influences the development of type 1 diabetes (T1D). We have previously shown that MyD88 …

The development of the microbiome from infancy to childhood is dependent on a range of
factors, with microbial–immune crosstalk during this time thought to be involved in the …

Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2
diabetes,. Previous metagenomic studies have described the characteristics of gut …