Trop2-targeted immunoPET imaging of solid tumors with a single domain antibody tracer

X Long, X Xia, W Wei, X Lan, D Jiang - 2024 - Soc Nuclear Med
241668 Introduction: Trophoblast cell surface antigen2 (Trop2) is a cell surface glycoprotein
overexpressed in many solid tumors while underexpressed in normal tissues, making it a …

ImmunoPET imaging of Trop2 in solid tumors: a translational study

W Wei, W Huang - 2024 - Soc Nuclear Med
242012 Introduction: Precision therapy has long been pursued. Accurately predicting and
selecting patients who can benefit from targeted or immunotherapy is crucial to realize …

ImmunoPET imaging of Trop2 in patients with solid tumours

W Huang, Y Zhang, M Cao, Y Wu, F Jiao… - EMBO Molecular …, 2024 - embopress.org
Accurately predicting and selecting patients who can benefit from targeted or
immunotherapy is crucial for precision therapy. Trophoblast cell surface antigen 2 (Trop2) …

ImmunoPET imaging of Trop2 expression in solid tumors with nanobody tracers

W Huang, C Liang, Y Zhang, D Zhang, S An… - European Journal of …, 2024 - Springer
Purpose The high expression of the transmembrane glycoprotein trophoblast cell-surface
antigen 2 (Trop2) was strongly associated with the progression of solid tumors, including …

ImmunoPET of trophoblast cell-surface antigen 2 (Trop-2) expression in pancreatic cancer

W Chen, M Li, MH Younis, TE Barnhart, D Jiang… - European journal of …, 2022 - Springer
Purpose Without a standard test for pancreatic carcinomas, this highly lethal disease is
normally diagnosed at its advanced stage, leading to a low survival rate of patients …

[PDF][PDF] Preclinical evaluation of the theranostic potential of 89 Zr/177 Lu‑labeled anti‑TROP‑2 antibody in triple‑negative breast cancer model

E Radiopharmacy - 2024 - ejnmmipharmchem.springeropen …
Background: Triple-negative breast cancer (TNBC) is one of the most lethal malignant
tumors among women, characterized by high invasiveness, high heterogeneity, and lack of …

68Ga-TROP2-Nanobody for PET/CT assessment of TROP2 expression in patients with various types of cancer

H Chen, J Shi, J Cai, W Xu, Y Sun, H Gao, Y Pang… - 2024 - Soc Nuclear Med
241598 Introduction: The trophoblast cell surface antigen 2 (TROP2) is a transmembrane
glycoprotein that regulates cell renewal and proliferation, and is found overexpressed in …

ImmunoPET: antibody-based PET imaging in solid tumors

R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

Preclinical evaluation of the theranostic potential of 89Zr/177Lu-labeled anti-TROP-2 antibody in triple-negative breast cancer model

Y Wu, T Li, X Zhang, H Jing, F Li, L Huo - EJNMMI Radiopharmacy and …, 2024 - Springer
Background Triple-negative breast cancer (TNBC) is one of the most lethal malignant tumors
among women, characterized by high invasiveness, high heterogeneity, and lack of specific …

Theranostic application of 64Cu/177Lu-labeled anti-Trop2 monoclonal antibody in pancreatic cancer tumor models

C Li, J Liu, X Yang, Q Yang, W Huang, M Zhang… - European Journal of …, 2022 - Springer
Purpose Pancreatic cancer is a malignant tumor with a high degree of malignancy, strong
heterogeneity, and high lethality. Trop2 is a transmembrane glycoprotein associated with the …