ALZHEIMER'S disease, a fatal neurodegenerative disorder of unknown aetiology, is usually
considered to be a single disorder because of tbe general uniformity of the disease …

Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a
very small proportion of early onset pedigrees being associated with mutations in the …

Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–
amyloid protein precursor gene located in 21q21. 3 have indicated that early–onset …

Alzheimer's disease is the most common form of dementia among the elderly population.
Although the etiology is unknown, inheritance plays a role in the pathogenesis of the …

(We have also identified two polymorphisms in the intronic sequences flanking this exon: An
A to C variant at nucleotide position-16 of the intron situated 3'of the exon; and an A to G …

Linkage analysis was used to search the genome for chromosomal regions harboring
familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant …

WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has
substantial nucleotide and amino-acid sequence similarity to the S182 gene on …

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several
families have been described in which Alzheimer's disease is caused by an autosomal …

Context.—The only genetic locus universally accepted to be important as a risk factor for late-
onset Alzheimer disease (AD) is the apolipoprotein E (APOE) locus on chromosome 19 …

Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …