Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder
PH St George-Hyslop, JL Haines, LA Farrer, R Polinsky… - Nature, 1990 - nature.com
ALZHEIMER'S disease, a fatal neurodegenerative disorder of unknown aetiology, is usually
considered to be a single disorder because of tbe general uniformity of the disease …
considered to be a single disorder because of tbe general uniformity of the disease …
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
P St George-Hyslop, J Haines, EI Rogaev, M Mortilla… - Nature …, 1992 - nature.com
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a
very small proportion of early onset pedigrees being associated with mutations in the …
very small proportion of early onset pedigrees being associated with mutations in the …
Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24. 3
C Van Broeckhoven, H Backhovens, M Cruts… - Nature …, 1992 - nature.com
Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–
amyloid protein precursor gene located in 21q21. 3 have indicated that early–onset …
amyloid protein precursor gene located in 21q21. 3 have indicated that early–onset …
Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease
GD Schellenberg, TD Bird, EM Wijsman, DK Moore… - Science, 1988 - science.org
Alzheimer's disease is the most common form of dementia among the elderly population.
Although the etiology is unknown, inheritance plays a role in the pathogenesis of the …
Although the etiology is unknown, inheritance plays a role in the pathogenesis of the …
[引用][C] Familial Alzheimer's chromosome 14 mutations
W Wasco, WP Pettingell, PD Jondro, SD Schmidt… - Nature medicine, 1995 - nature.com
(We have also identified two polymorphisms in the intronic sequences flanking this exon: An
A to C variant at nucleotide position-16 of the intron situated 3'of the exon; and an A to G …
A to C variant at nucleotide position-16 of the intron situated 3'of the exon; and an A to G …
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14
Linkage analysis was used to search the genome for chromosomal regions harboring
familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant …
familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant …
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
EI Rogaev, R Sherrington, EA Rogaeva, G Levesque… - Nature, 1995 - nature.com
WE report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has
substantial nucleotide and amino-acid sequence similarity to the S182 gene on …
substantial nucleotide and amino-acid sequence similarity to the S182 gene on …
The genetic defect causing familial Alzheimer's disease maps on chromosome 21
PH St George-Hyslop, RE Tanzi, RJ Polinsky… - Science, 1987 - science.org
Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several
families have been described in which Alzheimer's disease is caused by an autosomal …
families have been described in which Alzheimer's disease is caused by an autosomal …
Genetic studies on chromosome 12 in late-onset Alzheimer disease
WS Wu, P Holmans, F Wavrant-DeVrièze, S Shears… - Jama, 1998 - jamanetwork.com
Context.—The only genetic locus universally accepted to be important as a risk factor for late-
onset Alzheimer disease (AD) is the apolipoprotein E (APOE) locus on chromosome 19 …
onset Alzheimer disease (AD) is the apolipoprotein E (APOE) locus on chromosome 19 …
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene
RE Tanzi, PHS George-Hyslop, JL Haines, RJ Polinsky… - Nature, 1987 - nature.com
Amyloid β-protein (AP) is a peptide of relative molecular mass (M r) 42,000 found in the
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …
senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients …