Background Identifying polio vaccine regimens that can elicit robust intestinal mucosal
immunity and interrupt viral transmission is a key priority of the polio endgame. Methods In a …

To assess an immunization schedule combining oral (OPV) and inactivated poliovirus
vaccines (IPV), a clinical trial was conducted in The Gambia, Oman, and Thailand. Children …

Background The live vaccines bacille Calmette-Guérin (BCG) and measles vaccine have
beneficial nonspecific effects (NSEs) reducing mortality, more than can be explained by …

With the COVID-19 pandemic abating, the only remaining Public Health Emergency of
International Concern is polio [1]. Remarkable progress has been made in reducing the …

Background We conducted a clinical trial of fractional doses of inactivated poliovirus vaccine
administered to infants in Oman, in order to evaluate strategies for making the vaccine …

Infectious diarrhoea is one leading cause of infantile mortality in developing countries.
Rotaviruses and other enteroviruses have an important role in diarrhoea but, currently, there …

The Global Polio Eradication Initiative (GPEI) made rapid progress after its launch by the
World Health Assembly in 1988, reducing polio cases by more than 99% from an estimated …

The low efficiency of trivalent oral polio vaccine (TOPV) in inducing protective antibody titres
to polio3 is a problem of great importance in many regions of the world. A prospective study …

Background Prior analyses demonstrated the need for some countries and the Global Polio
Eradication Initiative (GPEI) to conduct additional supplemental immunization activities …

After exposure to the oral poliovirus vaccine (OPV), immunocompetent persons excrete
poliovirus (PV) vaccine strains for a limited period. In contrast, immunodeficient individuals …