Two patients with longstanding adrenal insufficiency developed severe mineralocorticoid
deficiency during concomitant phenytoin treatment. A 64-year-old man with primary adrenal …

The three major adrenal mineralocorticoid hormones are aldosterone, deoxycorticosterone
(DOC) and corticosterone (B). To date, there are four recognized types of primary …

Chronic administration of antiepileptic agents such as phenytoin can increase clearance
rates of cortisol and synthetic glucocorticoids through hepatic microsomal enzyme induction …

MATERIALS AND METHODS All the adrenal glands were obtained by surgery and
immediately iced until used. Adrenals were weighed, sectioned, freed of fat, reweighed, and …

Abstract T HE INTRODUCTION of desoxycorticosterone for the treatment of Addison's
disease was a significant advance in medicine (62). This hormone tends to correct the …

A 36-yr-old woman with a chronic wasting illness associated with hyponatremia and
hypotension proved to have secondary adrenal insufficiency and low levels of GH and PRL …

Background Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC)
replacement therapy. Within tissues, cortisol (F) availability is under the control of the …

Case-reports have made it evident that both inhaled, percutaneous, intranasal, intraarticular
and ophthalmic administered glucocorticoids have the potential to cause life threatening …

Abstract The aldosterone antagonist, SC-8109, was administered to a patient with clinical
and biochemical evidence suggesting mineralocorticoid excess. There was an increase in …

Administration of adrenocortical steroids is known to depress adrenocortical function. After
Sayers & Sayers (1949) had demonstrated that adrenocortical steroids can inhibit the …