Clinical applications of antimicrobial peptides (AMPs): where do we stand now?

M Divyashree, MK Mani, D Reddy… - Protein and peptide …, 2020 - ingentaconnect.com
In this era of multi-drug resistance (MDR), antimicrobial peptides (AMPs) are one of the most
promising classes of potential drug candidates to combat communicable as well as …

Designing and optimizing new antimicrobial peptides: all targets are not the same

A Barreto-Santamaría, ME Patarroyo… - Critical Reviews in …, 2019 - Taylor & Francis
Because the resistance of microorganisms to the available antibiotics is a growing
healthcare problem worldwide, the search for new antimicrobial peptides (AMPs) that …

[HTML][HTML] Antimicrobial peptides and proteins: from nature's reservoir to the laboratory and beyond

T Sarkar, M Chetia, S Chatterjee - Frontiers in Chemistry, 2021 - frontiersin.org
Rapid rise of antimicrobial resistance against conventional antimicrobials, resurgence of
multidrug resistant microbes and the slowdown in the development of new classes of …

Antimicrobial peptides: premises and promises

KVR Reddy, RD Yedery, C Aranha - International journal of antimicrobial …, 2004 - Elsevier
Antimicrobial peptides (AMPs) are an important component of the natural defences of most
living organisms against invading pathogens. These are relatively small (< 10kDa), cationic …

Development and challenges of antimicrobial peptides for therapeutic applications

CH Chen, TK Lu - Antibiotics, 2020 - mdpi.com
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …

[HTML][HTML] Chemical modifications to increase the therapeutic potential of antimicrobial peptides

Y Han, M Zhang, R Lai, Z Zhang - Peptides, 2021 - Elsevier
The continued use of antibiotics has been accompanied by the rapid emergence and spread
of antibiotic-resistant strains of bacteria. Antimicrobial peptides (AMPs), also known as host …

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

U Piotrowska, M Sobczak… - Chemical Biology & Drug …, 2017 - Wiley Online Library
Micro‐organism resistance is an important challenge in modern medicine due to the global
uncontrolled use of antibiotics. Natural and synthetic antimicrobial peptides (AMP s) …

How to combat gram-negative bacteria using antimicrobial peptides: a challenge or an unattainable goal?

A Barreto-Santamaría, G Arévalo-Pinzón, MA Patarroyo… - Antibiotics, 2021 - mdpi.com
Antimicrobial peptides (AMPs) represent a promising and effective alternative for combating
pathogens, having some advantages compared to conventional antibiotics. However, AMPs …

Strategies for recombinant production of antimicrobial peptides with pharmacological potential

KB Sampaio de Oliveira, ML Leite… - Expert review of …, 2020 - Taylor & Francis
Introduction The need to develop new drugs for the control of pathogenic microorganisms
has redoubled efforts to prospect for antimicrobial peptides (AMPs) from natural sources and …

[HTML][HTML] Lessons learned from clinical trials using antimicrobial peptides (AMPs)

GS Dijksteel, MMW Ulrich, E Middelkoop… - Frontiers in …, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …