Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood

CA Dannenhoffer, A Gómez‐A… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Binge alcohol exposure during adolescence results in long‐lasting alterations
in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in …

Effects of adolescent intermittent ethanol exposure on cortical perineuronal net and parvalbumin expression in adulthood mediate behavioral inflexibility

EDK Sullivan, CA Dannenhoffer… - Alcohol: Clinical and …, 2024 - Wiley Online Library
Background Alcohol is commonly consumed by adolescents in a binge‐like pattern, which
can lead to long‐lasting cognitive deficits, including reduced behavioral flexibility. We and …

Repeated binge drinking increases perineuronal nets in the insular cortex

H Chen, D He, AW Lasek - Alcoholism: Clinical and …, 2015 - Wiley Online Library
Background Alcohol exposure leads to changes in the extracellular matrix (ECM) in the
brain, which profoundly impacts neuronal plasticity. Perineuronal nets (PN s) are specialized …

Diverging effects of adolescent ethanol exposure on tripartite synaptic development across prefrontal cortex subregions

CD Walker, HG Sexton, J Hyde, B Greene, ML Risher - Cells, 2022 - mdpi.com
Adolescence is a developmental period that encompasses, but is not limited to, puberty and
continues into early adulthood. During this period, maturation and refinement are observed …

Persistent alterations of accumbal cholinergic interneurons and cognitive dysfunction after adolescent intermittent ethanol exposure

E Galaj, BT Kipp, SB Floresco, LM Savage - Neuroscience, 2019 - Elsevier
Adolescent binge drinking renders young drinkers vulnerable to alcohol use disorders in
adulthood; therefore, understanding alcohol-induced brain damage and associated …

[HTML][HTML] Adolescent intermittent ethanol exposure reduces astrocyte-synaptic proximity in the adult medial prefrontal cortex in rats: Reversal by gabapentin

KL Healey, A Bell, MD Scofield, HS Swartzwelder - Addiction neuroscience, 2022 - Elsevier
Alcohol consumption in adolescence causes multiple acute negative changes in neural and
behavioral function that persist well into adulthood and possibly throughout life. The medial …

Effects of ethanol on persistent activity and up‐states in excitatory and inhibitory neurons in prefrontal cortex

JJ Woodward, MJ Pava - Alcoholism: Clinical and …, 2009 - Wiley Online Library
Background: Elucidating mechanisms that underlie the neural actions of ethanol is critical for
understanding how this drug affects behavior. Increasing evidence suggests that, in addition …

Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood

ML Risher, RL Fleming, WC Risher… - Alcoholism: Clinical …, 2015 - Wiley Online Library
Background Human adolescence is a crucial stage of neurological development during
which ethanol (EtOH) consumption is often at its highest. Alcohol abuse during adolescence …

Chronic gestational exposure to ethanol leads to enduring aberrances in cortical form and function in the medial prefrontal cortex

AGJ Skorput, HH Yeh - Alcoholism: Clinical and Experimental …, 2016 - Wiley Online Library
Background Exposure to ethanol (EtOH) in utero alters the disposition of tangentially
migrating GABA ergic interneurons in the fetal brain. The medial ganglionic eminence …

Adolescent alcohol exposure decreases frontostriatal resting‐state functional connectivity in adulthood

MA Broadwater, SH Lee, Y Yu, H Zhu… - Addiction …, 2018 - Wiley Online Library
Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with
emergence of adult executive function and top‐down inhibitory control over behavior …