Cytokines and growth factors are key regulators of immune activation, vascular alteration
and excessive production of extracellular matrix which are hallmark events in the …

ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Pathogenic processes that underlie the development and progression of systemic sclerosis
(SSc) are being defined in preclinical, clinical and genetic studies. Important evidence of …

Systemic sclerosis (SSc) is a complex rheumatologic autoimmune disease in which
inflammation, fibrosis, and vasculopathy share several pathogenic pathways that lead to …

Systemic sclerosis (SSc) is a systemic, immune-mediated chronic disorder characterized by
small vessel alterations and progressive fibrosis of the skin and internal organs. The …

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

A better understanding of SSc pathogenesis will allow the development of novel therapeutic
strategies targeting specific cell types and the pathways that are abnormally activated as …

Systemic sclerosis (SSc or scleroderma) is a progressive and highly debilitating
autoimmune disorder characterized by inflammation, vasculopathy, and extensive fibrosis …

Systemic sclerosis (SSc), also known as scleroderma, is a complex connective tissue
disease that is associated with a high mortality and is challenging to treat because of its …

Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …