Cancer is discussed from a standpoint of a postembryonic differentiation. A differentiation
requires the interaction of an exogenous inductive stimulus with competent precursor cell …

Publisher Summary The chapter discusses the normal stem-cell systems, evidence for the
aberrant developmental nature of tumors, first through examples of spontaneous …

A concept of neoplasms, based upon developmental and oncological principles, states that
carcinomas are caricatures of tissue renewal, in that they are composed of a mixture of …

Analysis of the cellular origin of carcinomas of different organs indicates that there is in each
instance, a determined stem cell required for tissue renewal that is the cell of origin for …

The cells in the body descend from precursors known as stem cells. Stem cells can multiply
rapidly; their progeny, after matur ing and differentiating into specialized forms, generally …

Evidence has been presented to support the concept that malignant tumors are
postembryonic differentiations superimposed upon the process of tissue maintenance and …

The stem cell concept continues to be very useful both for studies on cellular differentiation
and for studies on neoplasia. At present the concept is being enlarged to include …

Our forefathers in pathology, on observing cancer tissue under the microscope in the mid-
19th century, noticed the similarity between embryonic tissue and cancer, and suggested …

THE GREAT HONOR that you have awarded me today was unanticipated, and the more
treasured because the Association also honors Professor Rous and Professor Whipple …

The precise mechanism (s) whereby normal cells become malignant are not known with any
degree of certainty. However, many mechanisms have been proposed on the basis of …