Pregabalin (Lyrica™) is a novel amino acid compound that binds with high affinity to the
alpha2–delta (α2–δ) auxiliary protein of voltage-gated calcium channels. In vivo, it potently …

Purpose: Pregabalin (PGB) is an α2‐δ ligand with demonstrated efficacy in epilepsy,
neuropathic pain, and anxiety disorders. PGB is highly efficacious as adjunctive therapy in …

Introduction: Pregabalin, the S-enantiomer of 3-aminomethyl-5-methylhaxanoic acid, is a
second-generation antiepileptic drug (AED) developed after gabapentin with improved …

Chronic 'pathological'pain is sustained by mechanisms of peripheral and central
sensitization, which are being increasingly investigated at the molecular and cellular levels …

Background Pregabalin inhibits release of excess excitatory neurotransmitters, presumably
by binding to the α 2-δ subunit protein of widely distributed voltage-dependent calcium …

Pregabalin is a new anxiolytic that acts as a presynaptic inhibitor of the release of excessive
levels of excitatory neurotransmitters by selectively binding to the α 2-δ subunit of voltage …

J. Neurochem.(2010) 113, 552–561. Abstract Pregabalin is an anti‐convulsant that
successfully treats many neuropathic pain syndromes, although the mechanism of its anti …

Background Clinical management of neuropathic pain, which is pain arising as a
consequence of a lesion or a disease affecting the somatosensory system, partly relies on …

Neuropathic pain results from damage to the peripheral sensory nervous system, which may
have a number of causes. The calcium channel subunit α2δ-1 is upregulated in dorsal root …

Used mainly for the management of neuropathic pain, pregabalin is a gabapentinoid or
anticonvulsant that was initially developed as an antiepileptic agent. After more than a …