Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …

Melanoma is one of the most common cutaneous cancers worldwide. Activating mutations in
RAS oncogenes are found in a third of all human cancers and NRAS mutations are found in …

In 2013, new insights on the molecular features of cutaneous melanoma provided a
paradigm shift in our understanding of the biology of this disease. Exploiting immune …

Larger clinical trials are needed to fully define the efficacy of BRAF and CKIT-directed
therapy in melanoma, but early results suggest that this strategy will transform treatment …

Melanoma skin cancer is derived from skin melanocytes and has a high risk of metastatic
spread. Many clinical attributes and risk factors associated with melanoma have been well …

Recent efforts in genomic research have enabled the characterization of molecular
mechanisms underlying many types of cancers, ushering novel approaches for diagnosis …

Melanoma is the most aggressive and deadly type of skin cancer. Surgical resection with or
without lymph node sampling is the standard of care for primary cutaneous melanoma …

Melanoma is a common cancer in the Western world with an increasing incidence. Sun
exposure is still considered to be the major risk factor for melanoma. The prognosis of …

In general, melanoma can be considered as a UV‐driven disease with an aggressive
metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal …

The identification of driver mutations in melanoma has changed the field of cancer treatment.
BRAF and NRAS mutations are predominant in melanoma and lead to overactivation of the …