A new strategy for the semisynthesis of the aromatic cassane-type diterpene taepeenin F (6)
is reported. The introduction of the methyl group at C-14, characteristic of the target …

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Activated macrophages mediate inflammation, as they release nitric oxide and pro-
inflammatory cytokines in various inflammatory diseases. Suppressing macrophage …

This study has found that dimethyl cardamonin (2′, 4′-dihydroxy-6′-methoxy-3′, 5′-
dimethylchalcone; DMC), a naturally occurring chalcone, showed potent anti-inflammatory …

gave after distillation 8 as a colorless oil [79%, bp 98-100 (0.07 mm)]: ir (neat) 2.80 (m) and
5.75 ĩ (s); 4H NMR 1.30 (3 H, trip-let, J= 7.0 Hz), 1.33 (3 H, triplet, J= 7.0 Hz), 1.57-2.55 (6 H …

Sesquiterpene acids are natural products that, in contrast with the thoroughly studied
sesquiterpene lactones, have received little pharmacological attention. A good source of this …

The inflammatory process is a mammalian physiological reaction against infectious agents
or injuries. Among the cells involved, the macrophages have a highlighted role during this …

Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and treatment
options for HCC are limited. In addition, the discovery of new natural compounds with anti …

Mogrol, the aglycone of well-known sweeter mogrosides, shows potent anti-inflammatory
activity. In this study, forty-two mogrol derivatives bearing various pharmacophores with …

Five new phorbol esters,(four phorbol diesters, 1–4, and one 4-deoxy-4α-phorbol diester, 5),
as well as four known phorbol esters analogues (6–9) were isolated and identified from the …