Vascular lipases including lipoprotein lipase (LPL), hepatic lipase (HL) and endothelial
lipase (EL) are important determinants of plasma lipid homeostasis and coronary artery …

Abstract Background Lipase Maturation Factor 1 (LMF1) is an ER-chaperone involved in the
post-translational maturation and catalytic activation of vascular lipases including lipoprotein …

Mutations in lipase maturation factor 1 (LMF1) are associated with severe
hypertriglyceridemia in mice and human subjects. The underlying cause is impaired lipid …

Objective—Lipoprotein lipase (LPL) is a principal enzyme in lipoprotein metabolism, tissue
lipid utilization, and energy metabolism. LPL is synthesized by parenchymal cells in …

Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein
involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and …

Nonalcoholic fatty liver disease (NAFLD), defined as hepatic steatosis resulting in> 5% of
the weight liver being triglycerides (TG), afflicts at least a quarter of Americans. NAFLD …

Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein
involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and …

Over a third of the US adult population has hypertriglyceridemia, resulting in an increased
risk of atherosclerosis, pancreatitis, and metabolic syndrome. Lipoprotein lipase (LPL), a …

LMF1 functions in the maturation of a selected group of secreted lipases that assemble into
homodimers in the endoplasmic reticulum. These dimeric lipases include lipoprotein lipase …

Over a third of the US adult population has elevated blood triglyceride (TG) levels
(hypertriglyceridemia), resulting in an increased risk of atherosclerosis, pancreatitis, and …