The higher organization of β-cells into spheroid structures termed islets of Langerhans is
critical for the proper regulation of insulin secretion. Thus, rodent β-cells form a functional …

The control of hormone secretion is central to body homeostasis, and its dysfunction is
important in many diseases. The key cellular steps that lead to hormone secretion have …

Close cellular proximity and correct anatomical arrangement within islets are essential for
normal patterns of insulin secretion. Thus, segregation of islets into single cells is associated …

Interactions between the endocrine cells in islets of Langerhans influence their secretory
function, and disruption of islet structure results in impaired insulin secretory responses to …

Blood glucose homeostasis requires proper function of pancreatic islets, which secrete
insulin, glucagon and somatostatin from the β-, α-and δ-cells respectively. Each islet cell …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

The human genome project and its search for factors underlying human diseases has
fostered a major human research effort. Therefore, unsurprisingly, in recent years we have …

The regulation of insulin secretion is under control of a complex inter-organ/cells crosstalk
involving various metabolites and/or physical connections. In this review, we try to illustrate …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

We have studied the effects of cell communication on human beta cell function and
resistance to cytotoxicity using the novel human insulin-secreting cell line 1.1 B4 configured …