Major histocompatibility complex class I (MHCI) genes were discovered unexpectedly in
healthy CNS neurons in a screen for genes regulated by neural activity. In mice lacking just …

Class I major histocompatibility complex (class I MHC) molecules, known to be important for
immune responses to antigen, are expressed also by neurons that undergo activity …

Proper development of the central nervous system (CNS) requires the establishment of
appropriate connections between neurons. Recent work suggests that this process is …

To elucidate molecular mechanisms underlying activity-dependent synaptic remodeling in
the developing mammalian visual system, we screened for genes whose expression in the …

Synapse pruning is an activity-regulated process needed for proper circuit sculpting in the
developing brain. Major histocompatibility class I (MHCI) molecules are regulated by activity …

Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …

For the nervous system to translate experience into memory and behavior, lasting structural
change at synapses must occur. This requirement is clearly evident during critical periods of …

The formation of precise connections between retina and lateral geniculate nucleus (LGN)
involves the activity-dependent elimination of some synapses, with strengthening and …

Experience can alter synaptic connectivity throughout life, but the degree of plasticity present
at each age is regulated by mechanisms that remain largely unknown. Here, we …

Immune molecules have been discovered recently to play critical roles in the development,
function, and plasticity of the cerebral cortex. MHC class I (MHCI) molecules are expressed …