Combinatorial peptide libraries: mining for cell-binding peptides
BP Gray, KC Brown - Chemical reviews, 2014 - ACS Publications
The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …
a unique cellular landscape specific to the type and state of the cell. Ligands that …
New approaches for cell-specific targeting: identification of cell-selective peptides from combinatorial libraries
KC Brown - Current opinion in chemical biology, 2000 - Elsevier
Peptides that recognize specific cell types promise to be valuable tools both in research and
clinical applications. Cell-specific peptides can be useful as drug delivery vehicles …
clinical applications. Cell-specific peptides can be useful as drug delivery vehicles …
Cancer-specific ligands identified from screening of peptide-display libraries
T Mori - Current Pharmaceutical Design, 2004 - ingentaconnect.com
Although monoclonal antibodies have demonstrated clinical potentials as tumor targeting
agents, poor tumor penetration of the antibodies due to the size of molecules and liver/bone …
agents, poor tumor penetration of the antibodies due to the size of molecules and liver/bone …
Evolving a peptide: library platforms and diversification strategies
K Bozovičar, T Bratkovič - International journal of molecular sciences, 2019 - mdpi.com
Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients,
versatile tools in drug discovery, and for drug delivery. They find themselves at the …
versatile tools in drug discovery, and for drug delivery. They find themselves at the …
[HTML][HTML] Combinatorial peptide library methods for immunobiology research
R Liu, AM Enstrom, KS Lam - Experimental hematology, 2003 - Elsevier
The field of combinatorial peptide chemistry has emerged as a powerful tool in the study of
many biological systems. This review focuses on combinatorial peptide library methodology …
many biological systems. This review focuses on combinatorial peptide library methodology …
Random peptide libraries
JK Scott, L Craig - Current Opinion in Biotechnology, 1994 - Elsevier
Over the past year, great strides have been made in the design of peptide libraries, and new
approaches have been developed for identifying peptide ligands. The libraries comprise …
approaches have been developed for identifying peptide ligands. The libraries comprise …
Tumor-targeting peptides from combinatorial libraries
Cancer is one of the major and leading causes of death worldwide. Two of the greatest
challenges in fighting cancer are early detection and effective treatments with no or …
challenges in fighting cancer are early detection and effective treatments with no or …
Encoded libraries of chemically modified peptides
C Heinis, G Winter - Current opinion in chemical biology, 2015 - Elsevier
Highlights•Display techniques allow the genetic encoding and screening of billions of
peptides.•Strategies were developed to chemically modify genetically encoded peptide …
peptides.•Strategies were developed to chemically modify genetically encoded peptide …
Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries
A collection of 60 cell lines derived from human tumors (NCI-60) has been widely explored
as a tool for anticancer drug discovery. Here, we profiled the cell surface of the NCI-60 by …
as a tool for anticancer drug discovery. Here, we profiled the cell surface of the NCI-60 by …
From combinatorial chemistry to cancer-targeting peptides
OH Aina, R Liu, JL Sutcliffe, J Marik… - Molecular …, 2007 - ACS Publications
Several monoclonal antibodies that target cell surface receptors have gained approval by
the US Food and Drug Administration and are widely used in the treatment of some cancers …
the US Food and Drug Administration and are widely used in the treatment of some cancers …