Human immunodeficiency virus type 1 monoclonal antibodies suppress acute simian-human immunodeficiency virus viremia and limit seeding of cell-associated viral …
Combination antiretroviral therapy (cART) administered shortly after human
immunodeficiency virus type 1 (HIV-1) infection can suppress viremia and limit seeding of …
immunodeficiency virus type 1 (HIV-1) infection can suppress viremia and limit seeding of …
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
AT McGuire, S Hoot, AM Dreyer, A Lippy… - Journal of Experimental …, 2013 - rupress.org
Broadly neutralizing antibodies (bnAbs) against HIV are believed to be a critical component
of the protective responses elicited by an effective HIV vaccine. Neutralizing antibodies …
of the protective responses elicited by an effective HIV vaccine. Neutralizing antibodies …
Neutralizing activity of broadly neutralizing anti-HIV-1 antibodies against clade B clinical isolates produced in peripheral blood mononuclear cells
YZ Cohen, JCC Lorenzi, MS Seaman… - Journal of …, 2018 - Am Soc Microbiol
Recently discovered broadly neutralizing antibodies (bNAbs) against HIV-1 demonstrate
extensive breadth and potency against diverse HIV-1 strains and represent a promising …
extensive breadth and potency against diverse HIV-1 strains and represent a promising …
Protective efficacy of broadly neutralizing antibodies with incomplete neutralization activity against simian-human immunodeficiency virus in rhesus monkeys
B Julg, D Sok, SD Schmidt, P Abbink… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT HIV broadly neutralizing antibodies (bnAbs) have been shown to occasionally
display unusual virus neutralization profiles with nonsigmoidal slopes and plateaus at< …
display unusual virus neutralization profiles with nonsigmoidal slopes and plateaus at< …
Broad neutralization coverage of HIV by multiple highly potent antibodies
LM Walker, M Huber, KJ Doores, E Falkowska… - Nature, 2011 - nature.com
Broadly neutralizing antibodies against highly variable viral pathogens are much sought
after to treat or protect against global circulating viruses. Here we probed the neutralizing …
after to treat or protect against global circulating viruses. Here we probed the neutralizing …
[HTML][HTML] Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer
Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We
characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) …
characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) …
[HTML][HTML] Human non-neutralizing HIV-1 envelope monoclonal antibodies limit the number of founder viruses during SHIV mucosal infection in rhesus macaques
S Santra, GD Tomaras, R Warrier, NI Nicely… - PLoS …, 2015 - journals.plos.org
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus
across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies …
across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies …
Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge
Neutralizing antibodies to the V2 apex antigenic region of the HIV-1 envelope (Env) trimer
are among the most prevalent cross-reactive antibodies elicited by natural infection. Two …
are among the most prevalent cross-reactive antibodies elicited by natural infection. Two …
Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01
Y Li, S O'Dell, LM Walker, X Wu, J Guenaga… - Journal of …, 2011 - Am Soc Microbiol
The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly
neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the …
neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the …
Lack of ADCC breadth of human nonneutralizing anti-HIV-1 antibodies
T Bruel, F Guivel-Benhassine, V Lorin… - Journal of …, 2017 - Am Soc Microbiol
Anti-human immunodeficiency virus type 1 (HIV-1) nonneutralizing antibodies (nnAbs)
capable of antibody-dependent cellular cytotoxicity (ADCC) have been identified as a …
capable of antibody-dependent cellular cytotoxicity (ADCC) have been identified as a …