Structure of the Chlamydia trachomatis immunodominant antigen Pgp3

A Galaleldeen, AB Taylor, D Chen… - Journal of Biological …, 2013 - ASBMB
Chlamydia trachomatis infection is the most common sexually transmitted bacterial disease.
Left untreated, it can lead to ectopic pregnancy, pelvic inflammatory disease, and infertility …

Characterization of Pgp3, a Chlamydia trachomatis Plasmid-Encoded Immunodominant Antigen

D Chen, L Lei, C Lu, A Galaleldeen, PJ Hart… - Journal of …, 2010 - Am Soc Microbiol
Human antibody recognition of Chlamydia trachomatis plasmid-encoded Pgp3 protein is
dependent on the native conformation of Pgp3. The structural basis for the conformation …

Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner

Z Li, Y Zhong, L Lei, Y Wu, S Wang, G Zhong - Bmc Microbiology, 2008 - Springer
Background C. trachomatis organisms carry a cryptic plasmid that encodes 8 open reading
frames designated as pORF1 to 8. It is not clear whether all 8 pORFs are expressed during …

Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37

S Hou, X Dong, Z Yang, Z Li, Q Liu… - Infection and …, 2015 - Am Soc Microbiol
Chlamydia trachomatis infection in the lower genital tract can ascend to and cause
pathologies in the upper genital tract, potentially leading to severe complications, such as …

Plasmid Negative Regulation of CPAF Expression Is Pgp4 Independent and Restricted to Invasive Chlamydia trachomatis Biovars

MJ Patton, CY Chen, C Yang, S McCorrister, C Grant… - MBio, 2018 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding
trachoma and sexually transmitted disease. C. trachomatis isolates are classified into 2 …

Efficacy of Pgp3 vaccination for Chlamydia urogenital tract infection depends on its native conformation

B Peng, S Zhong, Y Hua, Q Luo, W Dong… - Frontiers in …, 2022 - frontiersin.org
Urogenital tract infections with Chlamydia trachomatis have frequently been detected among
patients diagnosed with sexually transmitted infections, and such infections lead to …

Humoral immune response to plasmid protein pgp3 in patients with Chlamydia trachomatis infection

M Comanducci, R Manetti, L Bini, A Santucci… - Infection and …, 1994 - Am Soc Microbiol
We identified, by two-dimensional electrophoretic analysis and microsequencing, a protein
of Chlamydia trachomatis elementary bodies which corresponds to the polypeptide (pgp3) …

Chlamydia trachomatis plasmid gene protein 3 is essential for the establishment of persistent infection and associated immunopathology

C Yang, L Kari, L Lei, JH Carlson, L Ma, CE Couch… - MBio, 2020 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding
trachoma and sexually transmitted disease afflicting hundreds of millions of people globally …

All subtypes of the Pmp adhesin family are implicated in chlamydial virulence and show species‐specific function

E Becker, JH Hegemann - Microbiologyopen, 2014 - Wiley Online Library
The bacterial pathogens Chlamydia trachomatis and C. pneumoniae are obligate
intracellular parasites, cause a number of serious diseases, and can infect various cell types …

Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes

L Song, JH Carlson, WM Whitmire, L Kari… - Infection and …, 2013 - Am Soc Microbiol
Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract
and has global medical importance. The chlamydial plasmid plays an important role in the …