Update on psoriasis immunopathogenesis and targeted immunotherapy

SK Mahil, F Capon, JN Barker - Seminars in immunopathology, 2016 - Springer
Over recent years, significant progress has been made in characterisation of the underlying
pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with …

[HTML][HTML] From empirical to pathogenesis-based treatments for psoriasis

PCM van de Kerkhof - Journal of Investigative Dermatology, 2022 - Elsevier
Since the foundation of the European Society for Dermatological Research, pathogenesis of
psoriasis has been studied by many research groups, focusing on various compartments of …

Inflammation and psoriasis: a comprehensive review

AM Man, MS Orăsan, OA Hoteiuc… - International Journal of …, 2023 - mdpi.com
Psoriasis is an immune-mediated disease with a strong genetic component that brings many
challenges to sick individuals, such as chronic illness, and which has multiple associated …

The cytokine mediated molecular pathophysiology of psoriasis and its clinical implications

R Singh, S Koppu, PO Perche, SR Feldman - International journal of …, 2021 - mdpi.com
Psoriasis is the result of uncontrolled keratinocyte proliferation, and its pathogenesis
involves the dysregulation of the immune system. The interplay among cytokines released …

The genetic basis of psoriasis

F Capon - International journal of molecular sciences, 2017 - mdpi.com
Psoriasis is widely regarded as a multifactorial condition which is caused by the interaction
between inherited susceptibility alleles and environmental triggers. In the last decade …

Highly effective new treatments for psoriasis target the IL-23/Type 17 T cell autoimmune axis

J Kim, JG Krueger - Annual review of medicine, 2017 - annualreviews.org
Psoriasis vulgaris, affecting the skin, is one of the most common organ-specific autoimmune
diseases in humans. Until recently, psoriasis was treated by agents or approaches …

Scanning the immunopathogenesis of psoriasis

A Chiricozzi, P Romanelli, E Volpe… - International journal of …, 2018 - mdpi.com
Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Cytokines in psoriasis

CC de Alcantara, EMV Reiche, ANC Simão - Advances in clinical chemistry, 2021 - Elsevier
Psoriasis is chronic, immune-mediated, inflammatory disease with a multifactorial etiology
that affects the skin tissue and causes the appearance of dry and scaly lesions of anywhere …

Cellular mechanisms of psoriasis pathogenesis: a systemic review

M Wu, C Dai, F Zeng - Clinical, cosmetic and investigational …, 2023 - Taylor & Francis
Psoriasis is a common inflammatory skin disease characterized by abnormal proliferation of
epidermal keratinocytes and massive infiltration of inflammatory cells. Many kinds of cells …

Immunology of psoriasis

MA Lowes, M Suarez-Farinas… - Annual review of …, 2014 - annualreviews.org
The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …