Through their association with a kleisin subunit (Scc1), cohesin's Smc1 and Smc3 subunits
are thought to form tripartite rings that mediate sister chromatid cohesion. Unlike the …

During chromosome duplication the parental DNA molecule becomes overwound, or
positively supercoiled, in the region ahead of the advancing replication fork. To allow fork …

To understand how chromosome shapes are determined by actions of condensins and
cohesin, we devised a series of protocols in which their levels are precisely changed in …

Chromosome segregation, transcriptional regulation, and repair of DNA double-strand
breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes …

Background Condensin complexes organize chromosome structure and facilitate
chromosome segregation. Higher eukaryotes have two complexes, condensin I and …

Partitioning of chromatids during mitosis requires that chromosome compaction and spindle
length scale appropriately with each other. However, it is not clear whether chromosome …

The folding of genomic DNA from the beads-on-a-string-like structure of nucleosomes into
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …

Duplication and segregation of chromosomes involves dynamic reorganization of their
internal structure by conserved architectural proteins, including the structural maintenance of …

Complexes containing a pair of structural maintenance of chromosomes (SMC) family
proteins are fundamental for the three-dimensional (3D) organization of genomes in all …

The chromosomal condensin complex gives metaphase chromosomes structural stability. In
addition, condensin is required for sister-chromatid resolution during their segregation in …