Embryonic stem (ES) cells which have the unlimited proliferative capacity and extensive
differentiation potency can be an attractive source for kidney regeneration therapies. Recent …

Although renal transplantation has proved a successful treatment for the patients with end-
stage renal failure, the therapy is hampered by the problem of serious shortage of donor …

Directed differentiation of human pluripotent stem cells (hPSCs) uses a growing number of
small molecules and growth factors required for in vitro generation of renal lineage cells …

Glomerular injury and podocyte loss leads to secondary tubulointerstitial damage and the
development of fibrosis. The possibility of genetically reprogramming adult cells, termed …

Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed
multiple kidney-lineage cells and organoids. However, to further form functional segments of …

Forced expression of selected transcription factors can transform somatic cells into
embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is …

Embryonic stem cells and induced pluripotent stem cells have the ability to differentiate into
various organs and tissues, and are regarded as new tools for the elucidation of disease …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …

Renal disease is a major issue for global public health. Despite some progress in supportive
care, the mortality rates among patients with this condition remain alarmingly high. Studies …

Embryonic stem (ES) cells have been induced to differentiate in vitro into a broad spectrum
of specialized cell types, including hematopoietic, pancreatic, and neuronal cell types. Such …