Microsatellite instability (MSI) occurs in most tumours from patients with hereditary non-
polyposis colorectal cancer (HNPCC) and in around 17% of sporadic colorectal cancers …

Microsatellite instability is frequently seen in tumors from patients with hereditary
nonpolyposis colorectal cancer (HNPCC). Germline mutations in the mismatch repair gene …

The microsatellite instability that is a feature of tumors in patients with hereditary
nonpolyposis colorectal cancer (HNPCC) is a consequence of defective DNA mismatch …

Hereditary non-polyposis colorectal cancer (HNPCC) is linked to an inherited defect in the
DNA mismatch repair system. DNA from HNPCC tumours shows microsatellite instability …

Microsatellite instability (MSI) analysis was performed using a “reference panel” of
microsatellite markers in 345 unselected primary colorectal cancers (CRC). Thirty-five (10%) …

Genomic instability has been proposed as a new mechanism of carcinogenesis involved in
hereditary non-polyposis colorectal cancer (HNPCC) and in a large number of sporadic …

Germline mutations in the MSH2 and MLH1 mismatch repair genes account for most cases
of hereditary non-polyposis colon cancer syndrome (HNPCC). In addition, germline MSH2 …

BACKGROUND Clinical diagnosis of hereditary non-polyposis colorectal cancer (HNPCC)
is based on a typical family history. As molecular genetic testing is predominantly restricted …

To date, at least four genes involved in DNA mismatch repair, hMSH2, hMLHI, hPMSI and
hPMS2, have been demonstrated to be altered in the germline of patients with hereditary …

Hereditary nonpolyposis colorectal cancer (HNPCC) represents 2–4% of colorectal cancers
and is caused by a constitutional defect in a mismatch repair (MMR) gene, most commonly …