BACKGROUND: High throughput, brain-wide analysis of neural circuit connectivity is
needed to understand brain function across species. Combining such tractography …

Tractography combined with regions of interest (ROIs) has been used to non-invasively
study the structural connectivity of the cortex as well as to assess the reliability of these …

Interest in structural brain connectivity has grown with the understanding that abnormal
neural connections may play a role in neurologic and psychiatric diseases. Small animal …

Diffusion magnetic resonance imaging (dMRI) tractography has yielded intriguing insights
into brain circuits and their relationship to behavior in response to gene mutations or …

The striatum and cerebral cortex are interconnected via multiple recurrent loops that play a
major role in many neuropsychiatric conditions. Primate corticostriatal connections can be …

The human hypothalamus is at the center of the human limbic system anatomically and
physiologically. The hypothalamus plays pivotal roles in controlling autonomic responses …

Tractography based on diffusion MRI offers the promise of characterizing many aspects of
long-distance connectivity in the brain, but requires quantitative validation to assess its …

Detailed knowledge of the anatomy and connectivity pattern of cortico-basal ganglia circuits
is essential to an understanding of abnormal cortical function and pathophysiology …

The striatum is interconnected with the cerebral cortex via multiple recurrent loops that play
a major role in many neuropsychiatric conditions. Primate cortico-striatal connections can be …

The anatomical wiring of the brain is a central focus in network neuroscience. Diffusion MRI
tractography offers the unique opportunity to investigate the brain fiber architecture in vivo …