Critically ill patients are characterized by substantial pathophysiological changes that alter
the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is …

We assessed the population pharmacokinetics of high-dose continuous-infusion (HDCI)
meropenem in a cohort of patients with Klebsiella pneumoniae carbapenemase (KPC) …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …

Meropenem is one of the most frequently used antibiotics to treat life-threatening infections
in critically ill patients. This study aimed to develop a meropenem dosing algorithm for the …

Purpose Patients admitted to intensive care unit (ICU) with Klebsiella pneumoniae infections
are characterized by high mortality. The aims of the present study were to investigate the …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Background: The proper dosage of antibiotics is a key element in the effective treatment of
infection, especially in critically ill patients. This study aimed to evaluate the efficacy of …

The worrisome increase in Gram-negative bacteria with borderline susceptibility to
carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly …

Abstract Background and Objectives Meropenem is frequently used for the treatment of
severe bacterial infections in critically ill patients. Because critically ill patients are more …